Evidence map›Paper›PMID 33371009›Full record

ArticleBMJ open respiratory research2020

Expert artificial intelligence-based natural language processing characterises childhood asthma.

Hee Yun Seol, Mary C Rolfes, Wi Chung, Sunghwan Sohn, Euijung Ryu, Miguel A Park, Hirohito Kita, Junya Ono, Ivana Croghan, Sebastian M Armasu and 4 more

Open access · goldAbstract read
In one paragraph

Article in BMJ open respiratory research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. The evolution of scientific knowledge in childhood asthma over time.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Association of delayed asthma diagnosis with asthma exacerbations in children.The journal of allergy and clinical immunology. Global · 2025
    Article
  11. AI model for predicting asthma prognosis in children.The journal of allergy and clinical immunology. Global · 2025
    Article
  12. Sex differences in sociodemographic, clinical, and laboratory variables in childhood asthma: A birth cohort study.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2024
    Article
  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 3 countries.

Hee Yun SeolCommunity Pediatrics and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Mary C RolfesMayo Clinic Alix School of Medicine, Rocheser, Minnesota, USA.
Wi ChungCommunity Pediatrics and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Sunghwan SohnDigital Health Sciences, Mayo Clinic, Rochester, MN, United States.
Euijung RyuBiomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, United States.
Miguel A ParkAllergic Diseases, Mayo Clinic, Rochester, MN, United States.
Hirohito KitaAllergic Diseases, Mayo Clinic, Rochester, MN, United States.
Junya OnoResearch and Development Unit, Shino-Test Corporation, Sagamihara, Japan.
Ivana CroghanDepartment of Medicine, Mayo Clinic, Rochester, MN, United States.
Sebastian M ArmasuBiomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, United States.
Jose A Castro-RodriguezSchool of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
Jill D WestonCommunity Pediatrics and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Hongfang LiuDigital Health Sciences, Mayo Clinic, Rochester, MN, United States.
Young JuhnCommunity Pediatrics and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota, USA juhn.young@mayo.edu.
Mayo Clinic in Florida · USMayo Clinic in Arizona · USPontificia Universidad Católica de Chile · CLPusan National University Yangsan Hospital · KRShino-Test Corporation

Funding

Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
Rochester Epidemiology ProjectR01AG034676 · NIA · MAYO CLINIC ROCHESTER · PI ROCCA, WALTER A, ST SAUVER, JENNIFER LYNN · 2010 to 2019
$9.5M
Identification and characterization of children with asthma-associated comorbidities through computational and immune phenotypingR01HL126667 · NHLBI · MAYO CLINIC ROCHESTER · PI JUHN, YOUNG J, LIU, HONGFANG · 2015 to 2022
$4.3M
Enhanced Ascertainment of Asthma Status Via Natural Language ProcessingR21AI116839 · NIAID · MAYO CLINIC ROCHESTER · PI JUHN, YOUNG J, WU, STEPHEN TZE-INN · 2015 to 2016
$437k
Secondary use of EMR for residency training in asthma care and documentationR21AI142702 · NIAID · MAYO CLINIC ROCHESTER · PI JUHN, YOUNG J, SOHN, SUNGHWAN · 2019 to 2020
$437k
NCATS NIH HHS UL1 TR000135NHLBI NIH HHS R01 HL126667NIAID NIH HHS R21 AI116839NIAID NIH HHS R21 AI142702NIA NIH HHS R01 AG034676
6 · The paper itself

Abstract

introductionThe lack of effective, consistent, reproducible and efficient asthma ascertainment methods results in inconsistent asthma cohorts and study results for clinical trials or other studies. We aimed to assess whether application of expert artificial intelligence (AI)-based natural language processing (NLP) algorithms for two existing asthma criteria to electronic health records of a paediatric population systematically identifies childhood asthma and its subgroups with distinctive characteristics.

methodsUsing the 1997-2007 Olmsted County Birth Cohort, we applied validated NLP algorithms for Predetermined Asthma Criteria (NLP-PAC) as well as Asthma Predictive Index (NLP-API). We categorised subjects into four groups (both criteria positive (NLP-PAC

resultsOf the 8196 subjects (51% male, 80% white), we identified 1614 (20%), NLP-PAC

conclusionExpert AI-based NLP algorithms for two asthma criteria systematically identify childhood asthma with distinctive characteristics. This approach may improve precision, reproducibility, consistency and efficiency of large-scale clinical studies for asthma and enable population management.

Indexed as

AsthmaNatural Language ProcessingArtificial IntelligenceChildElectronic Health RecordsFemaleHumansMaleReproducibility of Resultsasthmaasthma epidemiologypaediatric asthma

Identifiers

PMID33371009
PMCPMC7011897
OpenAlexW3004446096

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.