Evidence map›Paper›PMID 33370992›Full record

ArticleBMJ case reports2020

Mycophenolate mofetil-induced liver injury in a patient with aquaporin-4 antibody positive transverse myelitis.

Arun Iyer, Madeleine Frank, Susan Davies, William T Gelson

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ case reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Arun IyerHepatology, Addenbrooke's Hospital, Cambridge, UK.
Madeleine FrankHepatology, Addenbrooke's Hospital, Cambridge, UK madeleinefrank@doctors.org.uk.
Susan DaviesHepatology, Addenbrooke's Hospital, Cambridge, UK.
William T GelsonHepatology, Addenbrooke's Hospital, Cambridge, UK.
Addenbrooke's Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present a case of a 49-year-old woman diagnosed with aquaporin-4 antibody-positive transverse myelitis, who developed a significant transaminitis 2 months after commencing mycophenolate mofetil (MMF) as a steroid-sparing agent. No other risk factors were identified, a blood liver panel was negative and liver biopsy showed features compatible with drug-induced liver injury (DILI). MMF was stopped with a corresponding normalisation of serum alanine aminotransferase over the next 2 months. This case highlights MMF as a rare cause of DILI and provides justification for monitoring of liver biochemistry on therapy.

Indexed as

Alanine TransaminaseAquaporin 4AutoantibodiesBiopsyChemical and Drug Induced Liver Injury, ChronicDrug SubstitutionFemaleHumansImmunosuppressive AgentsLiverMiddle AgedMycophenolic AcidMyelitis, TransverseRituximabAlanine TransaminaseAQP4 protein, humanAquaporin 4AutoantibodiesImmunosuppressive AgentsMycophenolic AcidRituximabdrugs: gastrointestinal systemunwanted effects / adverse reactions

Identifiers

PMID33370992
PMCPMC7757485
OpenAlexW3114499303

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.