Evidence map›Paper›PMID 33370954›Full record

ArticleBMJ case reports2020

Incidental finding of MEN-1 syndrome during staging and follow-up of breast carcinoma.

Bernardo Conde Maria, Ana Catarina Quadros, Natália Alves, João Coutinho

Open access · hybridAbstract readCase Reports
In one paragraph

Article in BMJ case reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Bernardo Conde MariaSurgery, Centro Hospitalar Lisboa Norte EPE, Lisboa, Portugal bmaria_4@hotmail.com.ORCID http://orcid.org/0000-0002-9814-4787
Ana Catarina QuadrosPathology, Centro Hospitalar Lisboa Norte EPE, Lisboa, Portugal.
Natália AlvesSurgery, Centro Hospitalar Lisboa Norte EPE, Lisboa, Portugal.
João CoutinhoSurgery, Centro Hospitalar Lisboa Norte EPE, Lisboa, Portugal.
Centro Hospitalar Lisboa Norte · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Type 1 multiple endocrine neoplasia (MEN-1) syndrome is an autosomal dominant disease, associated with germline mutations in the MEN-1 tumour suppressor gene (encoding the menin protein). Recent studies, through a better characterisation of the functions of the menin protein, have started to demonstrate how changes in this protein may be related to breast cancer. We present the case of a patient whose diagnosis of MEN-1 syndrome was made during treatment for a breast tumour-this diagnosis was obtained after finding multiple neoplastic lesions that fitted the MEN-1 syndrome spectrum, during the initial staging and subsequent follow-up of a breast tumour. In line with the growing evidence that links MEN-1 syndrome to breast cancer tumorigenesis, this case report highlights the following question: should we start screening this subset of patients earlier for breast cancer?

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsBreastBreast NeoplasmsCarcinoid TumorCarcinoma, Ductal, BreastFemaleGenetic CounselingGerm-Line MutationHumansIncidental FindingsLung NeoplasmsMagnetic Resonance ImagingMammographyMiddle AgedMultiple Endocrine Neoplasia Type 1MutationMEN1 protein, humanParathyroid HormoneProto-Oncogene Proteinsbreast cancerbreast surgerycancer intervention

Identifiers

PMID33370954
PMCPMC7754650
OpenAlexW3115464047

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.