Evidence map›Paper›PMID 33370502›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2021

Delayed graft function and acute rejection following HLA-incompatible living donor kidney transplantation.

Jennifer D Motter, Kyle R Jackson, Jane J Long, Madeleine M Waldram, Babak J Orandi, Robert A Montgomery, Mark D Stegall, Stanley C Jordan, Enrico Benedetti, Ty B Dunn and 32 more

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In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Characterizing the risk of human leukocyte antigen-incompatible living donor kidney transplantation in older recipients.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2023
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

42 authors at 20 institutions in 1 country.

Jennifer D MotterDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0003-1750-0119
Kyle R JacksonDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-8135-5377
Jane J LongDepartment of Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Madeleine M WaldramDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0001-5706-4353
Babak J OrandiDepartment of Surgery, University of Alabama, Birmingham, Alabama, USA.ORCID 0000-0001-6026-7135
Robert A MontgomeryNew York University Langone Medical Center, The NYU Transplant Institute, New York, New York, USA.
Mark D StegallDepartment of Surgery, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0002-1392-0792
Stanley C JordanDepartment of Medicine, Cedars-Sinai Comprehensive Transplant Center, Los Angeles, California, USA.
Enrico BenedettiDepartment of Surgery, University of Illinois-Chicago, Chicago, Illinois, USA.
Ty B DunnDepartment of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-5941-0659
Lloyd E RatnerDepartment of Surgery, Columbia University Medical Center, New York, New York, USA.
Sandip KapurDepartment of Surgery, New York Presbyterian/Weill Cornell Medical Center, New York, New York, USA.
Ronald P PelletierDepartment of Surgery, Robert Wood Johnson University Hospital, New Brunswick, New Jersey, USA.ORCID 0000-0001-6128-8333
John P RobertsDepartment of Surgery, University of California-San Francisco, San Francisco, California, USA.
Marc L MelcherDepartment of Surgery, Stanford University, Palo Alto, California, USA.
Pooja SinghDepartment of Medicine, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.
Debra L SudanDepartment of Surgery, Duke University Medical Center, Durham, North Carolina, USA.
Marc P PosnerDepartment of Surgery, Virginia Commonwealth University, Richmond, Virginia, USA.
Jose M El-AmmIntegris Baptist Medical Center, Transplant Division, Oklahoma City, Oklahoma, USA.
Ron ShapiroRecanati/Miller Transplantation Institute, Mount Sinai Hospital, New York, New York, USA.
Matthew CooperMedstar Georgetown Transplant Institute, Washington, District of Columbia, USA.
Jennifer E VerbeseyMedstar Georgetown Transplant Institute, Washington, District of Columbia, USA.
George S LipkowitzDepartment of Surgery, Baystate Medical Center, Springfield, Massachusetts, USA.
Michael A ReesDepartment of Urology, University of Toledo Medical Center, Toledo, Ohio, USA.
Christopher L MarshDepartment of Surgery, Scripps Clinic and Green Hospital, La Jolla, California, USA.
Bashir R SankariDepartment of Urology, Cleveland Clinic, Cleveland, Ohio, USA.
David A GerberDepartment of Surgery, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
Jason R WellenDepartment of Surgery, Barnes-Jewish Hospital, St. Louis, Missouri, USA.
Adel BozorgzadehDepartment of Surgery, University of Massachusetts Memorial Medical Center, Worcester, Massachusetts, USA.
A Osama GaberDepartment of Surgery, Houston Methodist Hospital, Houston, Texas, USA.
Eliot C HeherDepartment of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Francis L WengRenal and Pancreas Transplant Division, Saint Barnabas Medical Center, Livingston, New Jersey, USA.
Arjang DjamaliDepartment of Medicine, University of Wisconsin, Madison, Wisconsin, USA.ORCID 0000-0001-7675-6128
J Harold HeldermanDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Beatrice P ConcepcionDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Kenneth L BraymanDepartment of Surgery, University of Virginia, Charlottesville, Virginia, USA.
Jose OberholzerDepartment of Surgery, University of Virginia, Charlottesville, Virginia, USA.
Tomasz KozlowskiDepartment of Surgery, University of Florida, Gainesville, Florida, USA.
Karina CovarrubiasDepartment of Surgery, University of California San Diego, San Diego, California, USA.
Allan B MassieDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-5288-5125
Dorry L SegevDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-1924-4801
Jacqueline M Garonzik-WangDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Johns Hopkins University · USMayo Clinic · USMedStar Heart & Vascular Institute · USUniversity of Virginia · USVanderbilt University Medical Center · USBarnes-Jewish Hospital · USBaystate Medical Center · USCedars-Sinai Medical Center · USCleveland Clinic · USColumbia University Irving Medical Center · USCornell University · USDuke Medical Center · USINTEGRIS Baptist Medical Center · USMassachusetts General Hospital · USMemorial Medical Center · USMethodist Hospital · USMount Sinai Hospital · USNational Marrow Donor Program · USNYU Langone Health · USRobert Wood Johnson University Hospital · US

Funding

DEEP SOUTH TRANSLATIONAL RESEARCH MENTORED CAREER DEVELOPMENT PROGRAMKL2TR003097 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SAAG, KENNETH G · 2019 to 2023
$5.2M
Quantifying Risk And Survival Benefit from Incompatible Kidney TransplantationR01DK098431 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEGEV, DORRY L. · 2013 to 2017
$3.7M
Patient Oriented Research in Kidney Disease and Transplant SurgeryK24DK101828 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEGEV, DORRY L. · 2014 to 2018
$922k
Determinants of chronic kidney disease in African-American live kidney donorsK01DK101677 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI MASSIE, ALLAN B · 2015 to 2019
$789k
Aggressive Center Report Cards to Safely Increase Transplantation of Suboptimal KidneysK23DK115908 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI GARONZIK WANG, JACQUELINE M · 2018 to 2021
$516k
Differential Survival Benefit of Incompatible Living Donor Kidney Transplantation: Modeling Outcomes for Different Patient PhenotypesF32DK113719 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI JACKSON, KYLE R · 2017 to 2019
$238k
NCATS NIH HHS KL2 TR003097NIDDK NIH HHS F32 DK113719NIDDK NIH HHS K01 DK101677NIDDK NIH HHS K23 DK115908NIDDK NIH HHS K24 DK101828NIDDK NIH HHS R01 DK098431
6 · The paper itself

Abstract

Incompatible living donor kidney transplant recipients (ILDKTr) have pre-existing donor-specific antibody (DSA) that, despite desensitization, may persist or reappear with resulting consequences, including delayed graft function (DGF) and acute rejection (AR). To quantify the risk of DGF and AR in ILDKT and downstream effects, we compared 1406 ILDKTr to 17 542 compatible LDKT recipients (CLDKTr) using a 25-center cohort with novel SRTR linkage. We characterized DSA strength as positive Luminex, negative flow crossmatch (PLNF); positive flow, negative cytotoxic crossmatch (PFNC); or positive cytotoxic crossmatch (PCC). DGF occurred in 3.1% of CLDKT, 3.5% of PLNF, 5.7% of PFNC, and 7.6% of PCC recipients, which translated to higher DGF for PCC recipients (aOR =

Indexed as

Kidney TransplantationDelayed Graft FunctionGraft RejectionGraft SurvivalHumansLiving DonorsRetrospective StudiesRisk Factorsclinical research/practicedelayed graft function (DGF)desensitizationgraft survivalhistocompatibilitykidney transplantation/nephrologypatient survivalrejection: acute

Identifiers

PMID33370502
PMCPMC8016719
OpenAlexW3115172047

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.