Evidence map›Paper›PMID 33370344›Full record

ArticlePloS one2020

Association of serum 25-Hydroxy vitamin D with total and regional adiposity and cardiometabolic traits.

Reka Karuppusami, Belavendra Antonisami, Senthil K Vasan, Mahasampath Gowri, Hepsy Y Selliah, Geethanjali Arulappan, Felix Jebasingh, Nihal Thomas, Thomas V Paul

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Reka KaruppusamiDepartment of Biostatistics, Christian Medical College, Vellore, India.
Belavendra AntonisamiDepartment of Biostatistics, Christian Medical College, Vellore, India.
Senthil K VasanOxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, University of Oxford, Oxford, United Kingdom.
Mahasampath GowriDepartment of Biostatistics, Christian Medical College, Vellore, India.
Hepsy Y SelliahDepartment of Biostatistics, Christian Medical College, Vellore, India.
Geethanjali ArulappanDepartment of Clinical Biochemistry, Christian Medical College, Vellore, India.
Felix JebasinghDepartment of Endocrinology, Diabetes and Metabolism, Christian Medical College, Vellore, India.
Nihal ThomasDepartment of Endocrinology, Diabetes and Metabolism, Christian Medical College, Vellore, India.
Thomas V PaulDepartment of Endocrinology, Diabetes and Metabolism, Christian Medical College, Vellore, India.ORCID 0000-0003-3315-341X
Christian Medical College, Vellore · INChurchill Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLower serum 25-hydroxyvitamin D [25(OH)D] is associated with greater adiposity and adverse cardiometabolic risk profile. The evidence is inconsistent among South Asian Indians. We aimed to examine associations between 25(OH)D and cardiovascular (CVD) risk markers in a rural and urban cohort from South India. SUBJECTS/

methodsIn this cross sectional study, 373 individuals (men, n = 205) underwent detailed CVD risk marker assessment including anthropometry [body mass index (BMI), waist, (WC) and hip circumferences (HC)], body composition analysis using dual energy x-ray absorptiometry (DXA), blood pressure and biochemical analysis (glucose, insulin and lipids). The distribution of CVD risk factors were compared across serum 25(OH)D levels, stratified as deficiency (<20 ng/ml), insufficiency (20 to 29 ng/ml) and normal (≥30 ng/ml) levels. Multiple regression analysis, adjusting for potential confounders, was used to study associations of 25(OH)D with adiposity and cardiometabolic traits.

resultsThe mean and standard deviation (SD) of age, BMI and 25(OH)D levels were 41.4 (1.1) years, 25.5 (4.8) kg/m2 and 23.4 (10.4) ng/ml respectively. The prevalence of 25(OH)D deficiency was 39.9% in this cohort. Individuals in the 25(OH)D deficiency category had significantly higher mean (SD) BMI [26.6 (5.1) kg/m2], waist circumference [89.9 (12.5) cm] and total fat mass [20.6 (7.9) kg] compared with the Vitamin D sufficient group [BMI: 24.0 (4.4); WC 84.7 (12.0); total fat mass: 15.2 (6.8)]. Significantly inverse associations were observed with DXA measured total and regional fat depots with 25(OH)D levels, while anthropometric indices of adiposity showed significant inverse association only in women. After adjusting for total fat mass, no significant associations were observed between 25(OH)D and the cardiometabolic traits.

conclusionsOur results confirm that lower 25(OH)D is independently associated with both total and regional adiposity, but not with cardiometabolic traits, in this population.

Indexed as

AdiposityCardiometabolic Risk FactorsAdultFemaleHumansMaleSex CharacteristicsVitamin D25-hydroxyvitamin DVitamin D

Identifiers

PMID33370344
PMCPMC7769464
OpenAlexW3113738370

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.