ArticlePloS one2020
Clustering fibromyalgia patients: A combination of psychosocial and somatic factors leads to resilient coping in a subgroup of fibromyalgia patients.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cluster analysis in fibromyalgia: a systematic review.Rheumatology international · 2024Pooled it
- Exploring Emotional Eating and Emotion Dysregulation in Fibromyalgia Patients: Implications for Disease Management.Healthcare (Basel, Switzerland) · 2026Article
- Psychiatric comorbidity patterns across disability-based fibromyalgia phenotypes.CNS spectrums · 2026Article
- Moving Toward Objective Diagnosis in Fibromyalgia: Emerging Biomarkers and Digital Phenotyping Tools.Biomedicines · 2026Review
- Patient subtyping in juvenile fibromyalgia: the role of multisensory hypersensitivity and neurophysiological correlates.Journal of pediatric psychology · 2025Article
- Psychosocial aspects of rosacea: patient-reported coping strategies in Saudi Arabia.Frontiers in medicine · 2025Article
- Generative AI-based knowledge graphs for the illustration and development of mHealth self-management content.Frontiers in digital health · 2024Article
- Coping with fibromyalgia - a focus group study.International journal of qualitative studies on health and well-being · 2023Article
- Influence of socio-affective factors on quality of life in women diagnosed with fibromyalgia.Frontiers in psychology · 2023Article
- Coping and Beliefs as Predictors of Functioning and Psychological Adjustment in Fibromyalgia Subgroups.Pain research & management · 2022Article
- MiR103a-3p and miR107 are related to adaptive coping in a cluster of fibromyalgia patients.PloS one · 2020Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCoping strategies and their efficacy vary greatly in patients suffering from fibromyalgia syndrome (FMS).
objectiveWe aimed to identify somatic and psychosocial factors that might contribute to different coping strategies and resilience levels in FMS. SUBJECTS AND
methodsStandardized questionnaires were used to assess coping, pain, and psychological variables in a cohort of 156 FMS patients. Quantitative real-time polymerase chain reaction (qRT-PCR) determined gene expression of selected cytokines in white blood cells of 136 FMS patients and 25 healthy controls. Data of skin innervation, functional and structural sensory profiles of peripheral nociceptive nerve fibers of a previous study were included into the statistics. An exploratory factor analysis was used to define variance explaining factors, which were then included into cluster analysis.
results54.9% of the variance was explained by four factors which we termed (1) affective load, (2) coping, (3) pain, and (4) pro-inflammatory cytokines (p < 0.05). Considering differences in the emerged factors, coping strategies, cytokine profiles, and disability levels, 118 FMS patients could be categorized into four clusters which we named "maladaptive", "adaptive", "vulnerable", and "resilient" (p < 0.05). The adaptive cluster had low scores in disability and in all symptom categories in contrast to the vulnerable cluster, which was characterized by high scores in catastrophizing and disability (p < 0.05). The resilient vs. the maladaptive cluster was characterized by better coping and a less pro-inflammatory cytokine pattern (p < 0.05).
conclusionOur data suggest that problem- and emotion-focused coping strategies and an anti-inflammatory cytokine pattern are associated with reduced disability and might promote resilience. Additional personal factors such as low anxiety scores, ability of acceptance, and persistence further favor a resilient phenotype. Individualized therapy should take these factors into account.
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