ArticlePloS one2020
Association of an increase in serum albumin levels with positive 1-year outcomes in acute decompensated heart failure: A cohort study.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Red blood cell distribution width-albumin ratio as predictor of mortality in patients with cardiac disease: a systematic review and meta-analysis.BMC cardiovascular disorders · 2026Pooled it
- Pooled it
- A comparative study of intravenous polymyxin B and colistimethate sodium on efficacy, safety, and cost comparison in treating pulmonary infections: a retrospective cohort study.Frontiers in pharmacology · 2026Article
- Albumin, urea-to-albumin ratio, or the albumin-to-creatinine ratio to predict outcomes in heart failure with mildly reduced ejection fraction.European journal of clinical investigation · 2026Observational
- Long-term prognostic impact of in-hospital serum albumin concentration changes in patients hospitalised for heart failure.Open heart · 2025Article
- Prognostic value of the C-reactive protein-to-albumin ratio in acute decompensated heart failure across different glucose metabolism statuses.Scientific reports · 2025Article
- Age-stratified mortality and associated risk factors in adults aged 65 years or older undergoing continuous kidney replacement therapy: a consecutive retrospective study.BMC nephrology · 2025Article
- Clinical Impact of Early Changes in Serum Albumin on Patient Prognosis After Mitral-Transcatheter Edge-to-Edge Repair.Journal of the American Heart Association · 2025Article
- Association between neutrophil percentage-to-albumin ratio and prevalence peripheral artery disease in U.S. adults: a cross-sectional study from the NHANES.BMC cardiovascular disorders · 2025Article
- Impact of the hemoglobin-to-red cell distribution width ratio on 30-day readmission in patients with heart failure.BMC cardiovascular disorders · 2025Article
- Impact of advanced lung cancer inflammation index on all-cause mortality among patients with heart failure: a systematic review and meta-analysis with reconstructed time-to-event data.Cardio-oncology (London, England) · 2025Review
- Development and validation of a risk prediction model for 30-day readmission in elderly type 2 diabetes patients complicated with heart failure: a multicenter, retrospective study.Frontiers in endocrinology · 2025Article
- Derivation and Validation of Prediction Models for Prolonged Length of Stay and 30-Day Readmission in Elderly Patients With Type 2 Diabetes Mellitus: A Multicenter Study.Journal of diabetes research · 2025Article
- The Relationship between Serum Albumin Level and Quality of Life and Mortality in Patients with Heart Failure with Reduced Ejection Fraction.Research in heart yield and translational medicine · 2025Article
- The Relationship Between the Fibrinogen-to-Albumin Ratio and Short-Term Mortality in Chinese Patients With Chronic Heart Failure: A Retrospective Cohort Analysis.Cardiology research and practice · 2025Article
- An Albumin, Neutrophil, and Lymphocyte-Related Risk Estimation Tool in Hospitalised Patients.Cureus · 2024Article
- Combined Prognostic Impact of Low Muscle Mass and Hypoalbuminemia in Patients Hospitalized for Heart Failure: A Retrospective Cohort Study.Journal of the American Heart Association · 2024Article
- Associations between neutrophil-percentage-to-albumin ratio level and all-cause mortality and cardiovascular disease-cause mortality in general population: evidence from NHANES 1999-2010.Frontiers in cardiovascular medicine · 2024Article
- Association between serum albumin to serum creatinine ratio and mortality risk in patients with heart failure.Clinical and translational science · 2023Article
- Total 25-Hydroxyvitamin D Is an Independent Marker of Left Ventricular Ejection Fraction in Heart Failure with Reduced and Mildly Reduced Ejection Fraction.Biomolecules · 2023Article
Corrections and comments
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Authors and funding
31 authors at 20 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite the prognostic importance of hypoalbuminemia, the prognostic implication of a change in albumin levels has not been fully investigated during hospitalization in patients with acute decompensated heart failure (ADHF).
methodsUsing the data from the Kyoto Congestive Heart Failure registry on 3160 patients who were discharged alive for acute heart failure hospitalization and in whom the change in albumin levels was calculated at discharge, we evaluated the association with an increase in serum albumin levels from admission to discharge and clinical outcomes by a multivariable Cox hazard model. The primary outcome measure was a composite of all-cause death or hospitalization for heart failure.
findingsPatients with increased albumin levels (N = 1083, 34.3%) were younger and less often had smaller body mass index and renal dysfunction than those with no increase in albumin levels (N = 2077, 65.7%). Median follow-up was 475 days with a 96% 1-year follow-up rate. Relative to the group with no increase in albumin levels, the lower risk of the increased albumin group remained significant for the primary outcome measure (hazard ratio: 0.78, 95% confidence interval: 0.69-0.90: P = 0.0004) after adjusting for confounders including baseline albumin levels. When stratified by the quartiles of baseline albumin levels, the favorable effect of increased albumin was more pronounced in the lower quartiles of albumin levels, but without a significant interaction effect (interaction P = 0.49).
conclusionsIndependent of baseline albumin levels, an increase in albumin during index hospitalization was associated with a lower 1-year risk for a composite of all-cause death and hospitalization in patients with acute heart failure.
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