ArticlePLoS genetics2020
Physiological and genetic convergence supports hypoxia resistance in high-altitude songbirds.
Article in PLoS genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 23 citations in OpenAlex.
- Comparative and population genomics analyses of eared pheasants inhabiting highly varying altitudes.BMC genomics · 2026Article
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- DNA methylation-mediated regulation of hypoxia-responsive genes facilitates high-altitude adaptation in Tibetan chickens.Poultry science · 2026Article
- Red blood cells serve as a primary glucose sink to improve glucose tolerance at altitude.Cell metabolism · 2026Article
- Diverse mitogenomic variations contribute to population differentiation in Eurasian tree sparrows (Zoological research · 2026Article
- Article
- Acute hypoxia suppresses blood glycolysis in saker falcons (Zoological research · 2025Article
- Whole-genome relaxed selection and molecular constraints in Triplophysa under adapted Qinghai-Tibetan Plateau.BMC genomics · 2025Article
- Molecular regulation of reversible cardiac remodeling: lessons from species with extreme physiological adaptations.The Journal of experimental biology · 2024Review
- Bulk and single-cell alternative splicing analyses reveal roles of TRA2B in myogenic differentiation.Cell proliferation · 2024Article
- Metabolic and microbial changes in light-vented bulbul during recent northward range expansion.Current zoology · 2024Article
- Comparative transcriptomic and metabolomic analysis reveals pectoralis highland adaptation across altitudinal songbirds.Integrative zoology · 2022Article
- Identification of Signatures of Selection for Litter Size and Pubertal Initiation in Two Sheep Populations.Animals : an open access journal from MDPI · 2022Article
- Comparison between short-term stress and long-term adaptive responses reveal common paths to molecular adaptation.iScience · 2022Article
- Whole-genome resequencing provides insights into the population structure and domestication signatures of ducks in eastern China.BMC genomics · 2021Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skeletal muscle plays a central role in regulating glucose uptake and body metabolism; however, highland hypoxia is a severe challenge to aerobic metabolism in small endotherms. Therefore, understanding the physiological and genetic convergence of muscle hypoxia tolerance has a potential broad range of medical implications. Here we report and experimentally validate a common physiological mechanism across multiple high-altitude songbirds that improvement in insulin sensitivity contributes to glucose homeostasis, low oxygen consumption, and relative activity, and thus increases body weight. By contrast, low-altitude songbirds exhibit muscle loss, glucose intolerance, and increase energy expenditures under hypoxia. This adaptive mechanism is attributable to convergent missense mutations in the BNIP3L gene, and METTL8 gene that activates MEF2C expression in highlanders, which in turn increases hypoxia tolerance. Together, our findings from wild high-altitude songbirds suggest convergent physiological and genetic mechanisms of skeletal muscle in hypoxia resistance, which highlights the potentially medical implications of hypoxia-related metabolic diseases.
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