ArticleeLife2020
Diverse and complex muscle spindle afferent firing properties emerge from multiscale muscle mechanics.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Eight weeks of focal muscle vibration shows improvements in muscle co-ordination and co-contraction in cerebral palsy children: a randomized control trial.Journal of neuroengineering and rehabilitation · 2026Trial
- Cross-bridge model for predicting muscle short-range stiffness during movement.PLoS computational biology · 2026Article
- [Effectiveness Analysis of Cervical Rotation-Traction Manipulation on Cervical and Dorsal Muscle Tone in Patients With Cervical Spondylotic Radiculopathy].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Article
- A framework for quantifying the mechanics of dexterous grasp.bioRxiv : the preprint server for biology · 2026Article
- Proprioceptive integration in motor control.The Journal of physiology · 2026Article
- How temperature tunes muscle mechanics during eccentric contractions.American journal of physiology. Cell physiology · 2026Article
- Article
- Muscle spindles provide flexible sensory feedback for movement sequences.Cell reports · 2025Article
- Computing muscle mechanical state variables from combined proprioceptive sensory feedback.Experimental physiology · 2025Article
- Deep-learning models of the ascending proprioceptive pathway are subject to illusions.Experimental physiology · 2025Article
- Behavioural energetics in human locomotion: how energy use influences how we move.The Journal of experimental biology · 2025Review
- The Influence of Knee Proprioception and Strength on Lower-Limb Functional Symmetry in Healthy Adults.Muscles (Basel, Switzerland) · 2025Article
- Role of forelimb morphology in muscle sensorimotor functions during locomotion in the cat.The Journal of physiology · 2025Article
- Reduced rate of force development under fatigued conditions is associated to the decline in force complexity in adult males.European journal of applied physiology · 2024Article
- Neural networks simulating short-term memory of two inputs with varying commonality.bioRxiv : the preprint server for biology · 2024Article
- The functional role of the rabbit digastric muscle during mastication.The Journal of experimental biology · 2024Article
- Article
- Mechanosensory encoding of forces in walking uphill and downhill: force feedback can stabilize leg movements in stick insects.Journal of neurophysiology · 2024Article
- Attenuation of muscle spindle firing with artificially increased series compliance during stretch of relaxed muscle.Experimental physiology · 2024Article
- Intrafusal cross-bridge dynamics shape history-dependent muscle spindle responses to stretch.Experimental physiology · 2024Article
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Authors and funding
7 authors.
Funding
Abstract
Despite decades of research, we lack a mechanistic framework capable of predicting how movement-related signals are transformed into the diversity of muscle spindle afferent firing patterns observed experimentally, particularly in naturalistic behaviors. Here, a biophysical model demonstrates that well-known firing characteristics of mammalian muscle spindle Ia afferents - including movement history dependence, and nonlinear scaling with muscle stretch velocity - emerge from first principles of muscle contractile mechanics. Further, mechanical interactions of the muscle spindle with muscle-tendon dynamics reveal how motor commands to the muscle (alpha drive) versus muscle spindle (gamma drive) can cause highly variable and complex activity during active muscle contraction and muscle stretch that defy simple explanation. Depending on the neuromechanical conditions, the muscle spindle model output appears to 'encode' aspects of muscle force, yank, length, stiffness, velocity, and/or acceleration, providing an extendable, multiscale, biophysical framework for understanding and predicting proprioceptive sensory signals in health and disease.
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