Evidence map›Paper›PMID 33369884›Full record

ArticleDevelopmental neurobiology2021

Neuregulin-4 contributes to the establishment of cutaneous sensory innervation.

Laura Howard, Sean Wyatt, Alun M Davies

Open access · hybridAbstract read
In one paragraph

Article in Developmental neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Transcriptomic identification and developmental mapping ofTurkish journal of biology = Turk biyoloji dergisi · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Wiring the senses: Factors that regulate peripheral axon pathfinding in sensory systems.Developmental dynamics : an official publication of the American Association of Anatomists · 2023
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Laura HowardSchool of Biosciences, Cardiff University, Cardiff, UK.ORCID 0000-0002-5751-6185
Sean WyattSchool of Biosciences, Cardiff University, Cardiff, UK.ORCID 0000-0002-0572-234X
Alun M DaviesSchool of Biosciences, Cardiff University, Cardiff, UK.ORCID 0000-0001-5841-8176
Cardiff University · GB

Funding

Wellcome TrustWellcome Trust 103852
6 · The paper itself

Abstract

Recent work has shown that neuregulin-4 (NRG4) is a physiological regulator of the growth of sympathetic axons and CNS dendrites in the developing nervous system. Here, we have investigated whether NRG4 plays a role in sensory axon growth and the establishment of cutaneous sensory innervation. Imaging early nerve fibers in the well-characterized cutaneous trigeminal territory, the brachial plexus, and thorax revealed very marked and highly significant decreases in nerve fiber length and branching density in Nrg4

Indexed as

Nerve Growth FactorsAxonsNeuregulinsNeuronsNeurons, AfferentNerve Growth Factorsneuregulin-4Neuregulinsaxon growthcutaneous innervationNeuregulin-4sensory neuron

Identifiers

PMID33369884
PMCPMC8365430
OpenAlexW3117342937

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.