Evidence map›Paper›PMID 33369842›Full record

ArticleDiabetes/metabolism research and reviews2021

The SAGE study: Global observational analysis of glycaemic control, hypoglycaemia and diabetes management in T1DM.

Eric Renard, Hiroshi Ikegami, André Gustavo Daher Vianna, Paolo Pozzilli, Sandrine Brette, Zsolt Bosnyak, Felipe Lauand, Anne Peters, Valerie Pilorget, Dubravka Jurišić-Eržen and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Diabetes/metabolism research and reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.

  1. Real-World Evidence of Automated Insulin Delivery System Use.Diabetes technology & therapeutics · 2024
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  8. Tubeless Insulin Pump Combined with a Cloud-Based Data Management Platform: Real-World Evidence from 14,765 French People with Diabetes.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2025
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  13. Observational
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  16. Living with Type 1 Diabetes as Experienced by Adults with Prolonged Elevated HbA1c: A Qualitative Study.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2023
    Article
  17. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 11 institutions in 10 countries.

Eric RenardDepartment of Endocrinology, Diabetes, Nutrition, Montpellier University Hospital, INSERM Clinical Investigation Centre 1411, Institute of Functional Genomics, CNRS, INSERM, University of Montpellier, Montpellier, France.ORCID 0000-0002-3407-7263
Hiroshi IkegamiDepartment of Endocrinology, Metabolism and Diabetes, Kindai University Faculty of Medicine, Osaka, Japan.
André Gustavo Daher ViannaCuritiba Diabetes Center, Curitiba, Brazil.
Paolo PozzilliDepartment of Diabetes and Endocrinology, Unit of Endocrinology and Diabetes, Campus Bio-Medico University of Rome, Italy.
Sandrine BretteAixial, Boulogne-Billancourt, France.
Zsolt BosnyakSanofi, Paris, France.
Felipe LauandSanofi, Paris, France.
Anne PetersKeck School of Medicine, University of Southern California, Los Angeles, California, USA.
Valerie PilorgetSanofi, Paris, France.
Dubravka Jurišić-ErženDepartment of Endocrinology and Diabetology, Faculty of Medicine, University Hospital Centre, University of Rijeka, Rijeka, Croatia.
Jothydev KesavadevJothydev's Diabetes Research Centre, Kerala, India.
Jochen SeufertFaculty of Medicine, University of Freiburg, Freiburg, Germany.
Emma G WilmotDiabetes Department, University Hospitals of Derby and Burton, Derby, UK.
Sanofi (France) · FRCentre National de la Recherche Scientifique · FRCentro Universitário Curitiba · BRJothydev's Diabetes and Research Center · INKindai University · JPLaboratoire Vision Action Cognition · FRUniversità Campus Bio-Medico · ITUniversity Hospitals of Derby and Burton NHS Foundation Trust · GBUniversity of Freiburg · DEUniversity of Rijeka · HRUniversity of Southern California · US

Funding

New York Regional Center for Diabetes Translation Research - Translational Intervention Methodology CoreP30DK111022 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI JEFFREY GONZALEZ · 2016 to 2026
$7.8M
NIDDK NIH HHS P30 DK111022
6 · The paper itself

Abstract

aimsTo describe glycaemic control and diabetes management in adults with type 1 diabetes (T1DM), in a real-life global setting. MATERIALS AND

methodsStudy of Adults' GlycEmia (SAGE) was a multinational, multicentre, single visit, noninterventional, cross-sectional study in adult patients with T1DM. Data were collected at a single visit, analysed according to predefined age groups (26-44, 45-64 and ≥65 years) and reported across different regions. The primary endpoint was the proportion of participants achieving HbA

resultsOf 3903 included participants, 3858 (98.8%) were eligible for the study. Overall, 24.3% (95% confidence interval [CI]: 22.9-25.6) of participants achieved the glycaemic target of HbA

conclusionsGlycaemic control remains poor in adults with T1DM globally. Several areas of treatment may be optimised to improve outcomes, including supporting patient self-management of insulin therapy, increasing use of technologies such as CGM, and greater provision of healthcare support.

Indexed as

Diabetes Mellitus, Type 1HypoglycemiaAdultAgedCross-Sectional StudiesGlycated HemoglobinGlycemic ControlHumansHypoglycemic AgentsInsulinGlycated HemoglobinHypoglycemic AgentsInsulinadultsclinical practiceglobalglycaemic controlhypoglycaemiatype 1 diabetes

Identifiers

PMID33369842
PMCPMC8518876
OpenAlexW3116343197

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.