Evidence map›Paper›PMID 33369747›Full record

ArticleJournal of child psychology and psychiatry, and allied disciplines2021

Age of walking and intellectual ability in autism spectrum disorder and other neurodevelopmental disorders: a population-based study.

Alexandra Havdahl, Cristan Farmer, Synnve Schjølberg, Anne-Siri Øyen, Pål Surén, Ted Reichborn-Kjennerud, Per Magnus, Michaeline Bresnahan, Mady Hornig, Ezra Susser and 5 more

Open access · greenAbstract read
In one paragraph

Article in Journal of child psychology and psychiatry, and allied disciplines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 3 countries.

Alexandra HavdahlNic Waals Institute, Lovisenberg Diaconal Hospital, Oslo, Norway.ORCID 0000-0002-9268-0423
Cristan FarmerPediatrics & Developmental Neuroscience Branch, National Institute of Mental Health, Bethesda, MD, USA.
Synnve SchjølbergNorwegian Institute of Public Health, Oslo, Norway.
Anne-Siri ØyenNic Waals Institute, Lovisenberg Diaconal Hospital, Oslo, Norway.
Pål SurénNorwegian Institute of Public Health, Oslo, Norway.
Ted Reichborn-KjennerudNorwegian Institute of Public Health, Oslo, Norway.
Per MagnusNorwegian Institute of Public Health, Oslo, Norway.
Michaeline BresnahanNew York State Psychiatric Institute, Columbia University Medical Center, New York, NY, USA.
Mady HornigDepartment of Epidemiology, Mailman School of Public Health, New York, NY, USA.
Ezra SusserNew York State Psychiatric Institute, Columbia University Medical Center, New York, NY, USA.
W Ian LipkinDepartment of Epidemiology, Mailman School of Public Health, New York, NY, USA.
Catherine LordDavid Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Camilla StoltenbergNorwegian Institute of Public Health, Oslo, Norway.
Audrey ThurmPediatrics & Developmental Neuroscience Branch, National Institute of Mental Health, Bethesda, MD, USA.
Somer BishopUCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
Norwegian Institute of Public Health · NOColumbia University Irving Medical Center · USNational Institute of Mental Health · USColumbia University · USUniversity of California, Los Angeles · USUniversity of California, San Francisco · US

Funding

Gene-Environment Interactions in an Autism Birth CohortU01NS047537 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LIPKIN, W. IAN · 2003 to 2013
$27.0M
Neurodevelopmental and Behavioral Phenotyping ZICMH002961 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI THURM, AUDREY · 2017 to 2025
$12.6M
Development of a standardized measure of social-communication abilities for children with neurodevelopmental disordersR01HD093012 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BISHOP, SOMER L. · 2017 to 2022
$3.2M
Intramural NIH HHS ZIC MH002961Medical Research Council MC_UU_00011/1Medical Research Council MC_UU_12013/1NICHD NIH HHS R01 HD093012NINDS NIH HHS U01 NS047537
6 · The paper itself

Abstract

backgroundDelayed walking is common in intellectual disability (ID) but may be less common when ID occurs with autism spectrum disorder (ASD). Previous studies examining this were limited by reliance on clinical samples and exclusion of children with severe motor deficits.

objectiveTo examine in a population-based sample if age of walking is differentially related to intellectual ability in children with ASD versus other neurodevelopmental disorders (NDD).

methodsParticipants were from the nested Autism Birth Cohort Study of the Norwegian Mother, Father and Child Cohort Study (MoBa). Cox proportional hazards regression assessed if diagnosis (ASD n = 212 vs. NDD n = 354), continuous nonverbal IQ, and their interaction, were associated with continuous age of walking.

resultsThe relationship between nonverbal IQ and age of walking was stronger for NDD than for ASD (Group × nonverbal IQ interaction, χ

conclusionsThe finding that age of walking is less strongly related to low intellectual ability in children with ASD than in children without other NDDs supports the hypothesis that ID in ASD may result from heterogeneous developmental pathways. Late walking may be a useful stratification variable in etiological research focused on ASD and other NDDs.

Indexed as

Autism Spectrum DisorderIntellectual DisabilityNeurodevelopmental DisordersChildCohort StudiesHumansWalkingepidemiologygross motor milestonesIntellectual disabilitylate walkingMoBa

Identifiers

PMID33369747
PMCPMC8236490
OpenAlexW3114086444

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.