Evidence map›Paper›PMID 33369563›Full record

ArticleNeuroImage. Clinical2021

Arterial spin labeling brain MRI study to evaluate the impact of deafness on cerebral perfusion in 79 children before cochlear implantation.

Arnaud Coez, Ludovic Fillon, Ana Saitovitch, Caroline Rutten, Sandrine Marlin, Jennifer Boisgontier, Alice Vinçon-Leite, Hervé Lemaitre, David Grévent, Charles-Joris Roux and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 1 country.

Arnaud CoezService de radiologie pédiatrique, Hôpital Necker Enfants Malades, Assistance Publique Hôpitaux de Paris, APHP, Université de Paris, INSERM U1163, Institut Imagine, Paris, France; Service d'oto-rhino-laryngologie pédiatrique, Centre de Réference des Surdités Génétiques, Hôpital Necker Enfants Malades, AP-HP, Université de Paris, Paris, France; Laboratoire de correction auditive, Bizaguet, Paris, France; Institut de l'Audition, Paris, France. Electronic address: acoez@noos.fr.
Ludovic FillonService de radiologie pédiatrique, Hôpital Necker Enfants Malades, Assistance Publique Hôpitaux de Paris, APHP, Université de Paris, INSERM U1163, Institut Imagine, Paris, France.
Ana SaitovitchService de radiologie pédiatrique, Hôpital Necker Enfants Malades, Assistance Publique Hôpitaux de Paris, APHP, Université de Paris, INSERM U1163, Institut Imagine, Paris, France.
Caroline RuttenService de radiologie pédiatrique, Hôpital Necker Enfants Malades, Assistance Publique Hôpitaux de Paris, APHP, Université de Paris, INSERM U1163, Institut Imagine, Paris, France.
Sandrine MarlinService de Génétique Médicale, Centre de Référence des Surdités Génétiques, Hôpital Necker Enfants Malades, AP-HP, Université de Paris, Paris, France.
Jennifer BoisgontierService de radiologie pédiatrique, Hôpital Necker Enfants Malades, Assistance Publique Hôpitaux de Paris, APHP, Université de Paris, INSERM U1163, Institut Imagine, Paris, France.
Alice Vinçon-LeiteService de radiologie pédiatrique, Hôpital Necker Enfants Malades, Assistance Publique Hôpitaux de Paris, APHP, Université de Paris, INSERM U1163, Institut Imagine, Paris, France.
Hervé LemaitreService de radiologie pédiatrique, Hôpital Necker Enfants Malades, Assistance Publique Hôpitaux de Paris, APHP, Université de Paris, INSERM U1163, Institut Imagine, Paris, France.
David GréventService de radiologie pédiatrique, Hôpital Necker Enfants Malades, Assistance Publique Hôpitaux de Paris, APHP, Université de Paris, INSERM U1163, Institut Imagine, Paris, France.
Charles-Joris RouxService de radiologie pédiatrique, Hôpital Necker Enfants Malades, Assistance Publique Hôpitaux de Paris, APHP, Université de Paris, INSERM U1163, Institut Imagine, Paris, France.
Volodia Dangouloff-RosService de radiologie pédiatrique, Hôpital Necker Enfants Malades, Assistance Publique Hôpitaux de Paris, APHP, Université de Paris, INSERM U1163, Institut Imagine, Paris, France.
Raphaël LevyService de radiologie pédiatrique, Hôpital Necker Enfants Malades, Assistance Publique Hôpitaux de Paris, APHP, Université de Paris, INSERM U1163, Institut Imagine, Paris, France.
Eric BizaguetService d'oto-rhino-laryngologie pédiatrique, Centre de Réference des Surdités Génétiques, Hôpital Necker Enfants Malades, AP-HP, Université de Paris, Paris, France; Laboratoire de correction auditive, Bizaguet, Paris, France.
Isabelle RouillonService d'oto-rhino-laryngologie pédiatrique, Centre de Réference des Surdités Génétiques, Hôpital Necker Enfants Malades, AP-HP, Université de Paris, Paris, France.
Eréa Noël GarabédianService d'oto-rhino-laryngologie pédiatrique, Centre de Réference des Surdités Génétiques, Hôpital Necker Enfants Malades, AP-HP, Université de Paris, Paris, France.
Françoise DenoyelleService d'oto-rhino-laryngologie pédiatrique, Centre de Réference des Surdités Génétiques, Hôpital Necker Enfants Malades, AP-HP, Université de Paris, Paris, France; Institut de l'Audition, Paris, France.
Monica ZilboviciusService de radiologie pédiatrique, Hôpital Necker Enfants Malades, Assistance Publique Hôpitaux de Paris, APHP, Université de Paris, INSERM U1163, Institut Imagine, Paris, France; INSERM ERL "Developmental Trajectories & Psychiatry", Université Paris Saclay, Ecole Normale Supérieure Paris-Saclay, Université de Paris, CNRS, Centre Borelli, France.
Natalie LoundonService d'oto-rhino-laryngologie pédiatrique, Centre de Réference des Surdités Génétiques, Hôpital Necker Enfants Malades, AP-HP, Université de Paris, Paris, France; Institut de l'Audition, Paris, France.
Nathalie BoddaertService de radiologie pédiatrique, Hôpital Necker Enfants Malades, Assistance Publique Hôpitaux de Paris, APHP, Université de Paris, INSERM U1163, Institut Imagine, Paris, France; INSERM ERL "Developmental Trajectories & Psychiatry", Université Paris Saclay, Ecole Normale Supérieure Paris-Saclay, Université de Paris, CNRS, Centre Borelli, France.
Assistance Publique – Hôpitaux de Paris · FRHôpital Necker-Enfants Malades · FRInstitut des Maladies Génétiques Imagine · FRInserm · FRSorbonne Paris Cité · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Age at implantation is considered to be a major factor, influencing outcomes after pediatric cochlear implantation. In the absence of acoustic input, it has been proposed that cross-modal reorganization can be detrimental for adaptation to the new electrical input provided by a cochlear implant. Here, through a retrospective study, we aimed to investigate differences in cerebral blood flow (CBF) at rest prior to implantation in children with congenital deafness compared to normally hearing children. In addition, we looked at the putative link between pre-operative rest-CBF and the oral intelligibility scores at 12 months post-implantation. Finally, we observed the evolution of perfusion with age, within brain areas showing abnormal rest-CBF associated to deafness, in deaf children and in normally hearing children. In children older than 5 years old, results showed a significant bilateral hypoperfusion in temporal regions in deaf children, particularly in Heschl's gyrus, and a significant hyperperfusion of occipital regions. Furthermore, in children older than 5 years old, whole brain voxel-by-voxel correlation analysis between pre-operative rest-CBF and oral intelligibility scores at 12 months post-implantation, showed significant negative correlation localized in the occipital regions: children who performed worse in the speech perception test one year after implantation were those presenting higher preoperative CBF values in these occipital regions. Finally, when comparing mean relative perfusion (extracted from the temporal regions found abnormal on whole-brain voxel-based analysis) across ages in patients and controls, we observed that the temporal perfusion evolution was significantly different in deaf children than in normally hearing children. Indeed, while temporal perfusion increased with age in normally hearing children, it remained stable in deaf children. We showed a critical period around 4 years old, where in the context of auditory deprivation, there is a lack of synaptic activity in auditory regions. These results support the benefits of early cochlear implantation to maximize the effectiveness of auditory rehabilitation and to avoid cross-modal reorganization.

Indexed as

Cochlear ImplantationDeafnessSpeech PerceptionBrainCerebrovascular CirculationChildChild, PreschoolHumansMagnetic Resonance ImagingPerfusionRetrospective StudiesTreatment OutcomeArterial spin labelingAuditory cortexBrain developmentChildrenCochlear implant resultsDeafnessHearing lossMRIOral intelligibility scores

Identifiers

PMID33369563
PMCPMC7777537
OpenAlexW3108968339

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.