Evidence map›Paper›PMID 33369452›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2020

The Inter-Relation between Leptin Receptor (Q223R) Gene Polymorphism and the Risk of Egyptian Patients with HCC.

Hala A Karam, Sahar S Bessa, Ehab M M Ali, Thoria Diab, Tarek M Mohamed

Open access · goldAbstract read
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In one paragraph

Article in Asian Pacific journal of cancer prevention : APJCP, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.1field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Hala A KaramDepartment of Chemistry, Division of Biochemistry, Faculty of Science, Tanta University, Tanta, Egypt.
Sahar S BessaDepartment of Internal Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt.
Ehab M M AliDepartment of Biochemistry, Faculty of Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.ORCID 0000-0002-2475-0645
Thoria DiabDepartment of Chemistry, Division of Biochemistry, Faculty of Science, Tanta University, Tanta, Egypt.
Tarek M MohamedDepartment of Chemistry, Division of Biochemistry, Faculty of Science, Tanta University, Tanta, Egypt.
Tanta University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe relationship of leptin (LEP) and polymorphism of leptin receptor (LEPR) were studied in patients with hepatocellular carcinoma (HCC) and compared with those with liver cirrhosis to find out the extent of the risk of LEPR on patients with HCC.

methodsSerum LEP level and LEPR Q223R gene polymorphism were determined in 300 patients with liver disease categorized equally into five groups' healthy volunteers, patients with hepatitis C (HCV), patients with non-alcoholic steatohepatitis (NASH),  liver cirrhosis and HCC. LEPR gene was amplified by polymerase chain reaction (PCR) then digested by the MSP1 restriction enzyme.

resultsThe isolated 212 bp of LEPR was sequenced. The serum LEP level was reduced in patients with cirrhotic and HCC. Serum LEP level had negatively correlated with both tumor grade and size in HCC patients. The data obtained from restriction fragment length polymorphism‑PCR and sequencing revealed the existence of a novel synonymous Q223R single nucleotide polymorphism (SNP) in exon 223 of LEPR gene (1137101). LEPR Gln223Arg, GG and GA genotypes were found in all studied groups. LEPR Gln223Arg, AA genotype was found in NASH, HCC, and control. LEPR Gln223Arg GA genotype is associated with some patients with HCC.

conclusionGA genotype of LEPR Gln223Arg may be regarded as a probable genetic risk factor for Egyptian patients with HCC.

Indexed as

Biomarkers, TumorCarcinoma, HepatocellularCase-Control StudiesEgyptFemaleFollow-Up StudiesGenetic Predisposition to DiseaseHumansLeptinLiver NeoplasmsMaleMiddle AgedPolymorphism, Single NucleotidePrognosisReceptors, LeptinRisk FactorsBiomarkers, TumorLEPR protein, humanLeptinReceptors, LeptinHCCleptinLeptin receptorLiver Cirrhosis

Identifiers

PMID33369452
PMCPMC8046304
OpenAlexW3116002921

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.