ArticleJournal of biomedical optics2020
Effects of lipid composition on photothermal optical coherence tomography signals.
Article in Journal of biomedical optics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Phase-sensitive photothermal optical coherence tomography: decoupling optical and thermal tissue properties.Biomedical optics express · 2026Article
- Artificial neural network for enhancing signal-to-noise ratio and contrast in photothermal optical coherence tomography.Scientific reports · 2024Article
- Machine Learning-Assisted Short-Wave InfraRed (SWIR) Techniques for Biomedical Applications: Towards Personalized Medicine.Journal of personalized medicine · 2023Review
- Photothermal optical coherence tomography for 3D live cell detection and mapping.Optics continuum · 2023Article
- Three-dimensional opto-thermo-mechanical model for predicting photo-thermal optical coherence tomography responses in multilayer geometries.Biomedical optics express · 2022Article
- Spectroscopic thermo-elastic optical coherence tomography for tissue characterization.Biomedical optics express · 2022Article
- Transient-mode photothermal optical coherence tomography.Optics letters · 2021Article
- Handheld Thermo-Photonic Device for Rapid, Low-Cost, and On-Site Detection and Quantification of Anti-SARS-CoV-2 Antibody.IEEE sensors journal · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
significancePhotothermal optical coherence tomography (PT-OCT) has the promise to offer structural images coregistered with chemical composition information, which can offer a significant impact in early detection of diseases such as atherosclerosis.
aimWe take the first step in understanding the relation between PT-OCT signals and the endogenous tissue composition by considering the interplay between the opto-thermo-physical properties of tissue as a function of its lipid composition and the ensuing effects on the PT-OCT signals. APPROACH: Multiparameter theoretical estimates for PT-OCT signal as a function of composition in a two-component lipid-water model are derived and discussed. Experimental data from various concentrations of lipid in the form of droplets and injections under bovine cardiac muscle align with theoretical predictions.
resultsTheoretical and experimental results suggest that the variations of heat capacity and mass density with tissue composition significantly contribute to the amount of optical path length difference measured by OCT phase.
conclusionPT-OCT has the potential to offer key insights into the chemical composition of the subsurface lipid pools in tissue; however, the interpretation of results needs to be carried out by keeping the nonlinear interplay between the tissue of opto-thermo-physical properties and PT-OCT signals in mind.
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Registered trials
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