ArticleBrain and behavior2021
Reduced top-down attentional control in adolescents with generalized anxiety disorder.
Article in Brain and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Evidence from EEG of Abnormal Functional Connectivity and Microstates in GAD and PD.Brain topography · 2026Article
- Inflammation-related aberrations in beta and gamma oscillatory dynamics serving attention processing in typically developing youth.Brain communications · 2026Article
- Structural brain alterations in patients with anxious depression: evidence from the REST-meta-MDD project.Frontiers in psychiatry · 2025Article
- Multivariate Assessment of Inhibitory Control in Youth: Links With Psychopathology and Brain Function.Psychological science · 2024Article
- A Shared Multivariate Brain-Behavior Relationship in a Transdiagnostic Sample of Adolescents.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Neural correlates of automatic emotion regulation and their association with suicidal ideation in adolescents during the first 90-days of residential care.Translational psychiatry · 2024Article
- Altered brain function and structure pre- and post- COVID-19 infection: a longitudinal study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Temperamental Change in Adolescence and Its Predictive Role on Anxious Symptomatology.Behavioral sciences (Basel, Switzerland) · 2022Article
- Reduced cortical volume of the default mode network in adolescents with generalized anxiety disorder.Depression and anxiety · 2022Article
- Reduced top-down attentional control in adolescents with generalized anxiety disorder.Brain and behavior · 2021Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundGeneralized anxiety disorder (GAD) can significantly impair quality of life and is associated with a relatively poor long-term prognosis. Anxiety disorders are often associated with hyper-responsiveness to threat, perhaps coupled with impaired executive functioning. However, GAD, particularly adolescent GAD, has been the focus of little functional neuroimaging work compared to other anxiety disorders. Here, we examine the neural association of adolescent GAD with responsiveness to threat and response control.
methodsThe study involved 35 adolescents with GAD and 34 healthy comparison individuals (N = 69) matched on age, gender, and IQ. Participants were scanned during an affective number Stroop task.
resultsWe found significant Group-by-Task Condition interactions in regions involved in response control/motor responding (bilateral precentral gyri and cerebellum) and/or cognitive control/attention (dorsomedial and lateral frontal cortex, posterior cingulate cortex, cuneus, and precuneus). In line with predictions, the youth with GAD showed significantly less recruitment during task trials than the healthy comparison individuals. However, no indications of specific heightened responses to threat were seen.
conclusionsGAD involves reduced capacity for engaging regions involved in response control/motor responding and/or cognitive control/attention. This might reflect either a secondary consequence of the patient's worry or an early risk factor for the development of worry.
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