ArticleBrain and behavior2021
Electrocorticographic description of the effects of anticonvulsant drugs used to treat lidocaine-induced seizures.
Article in Brain and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 8 citations in OpenAlex.
- High Doses of Melatonin Induce Seizure-like Cortical Activity: Electrophysiological and Behavioral Evidence.ACS omega · 2026Article
- Lippia origanoides essential oil possesses anticonvulsant effect in pentylenetetrazol-induced seizures in rats: a behavioral, electroencephalographic, and electromyographic study.Frontiers in pharmacology · 2023Article
- 100 YEARS OF VITAMIN D: Supraphysiological doses of vitamin D changes brainwave activity patterns in rats.Endocrine connections · 2022Article
- Benzodiazepine partially reverses tonic-clonic seizures induced by thiocolchicoside.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2022Article
- A Combination ofFrontiers in cellular neuroscience · 2022Article
- Electrocorticographic description of the effects of anticonvulsant drugs used to treat lidocaine-induced seizures.Brain and behavior · 2021Article
- Increased Relative Delta Bandpower and Delta Indices Revealed by Continuous qEEG Monitoring in a Rat Model of Ischemia-Reperfusion.Frontiers in neurology · 2021Article
- Characterization of electrocorticographic, electromyographic and electrocardiographic recordings after the use of caffeine in Wistar rats.Einstein (Sao Paulo, Brazil) · 2021Article
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Authors and funding
11 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
introductionLocal anesthetics are widely used in clinical practice. While toxicity is rare, these drugs can cause potentially lethal seizures.
objectiveIn the present study, we investigated the electrocorticographic (ECoG) and electromyographic patterns of seizures induced by acute lidocaine (LA) toxicity and treated with anticonvulsant drugs. The study used adult male Wistar rats to describe of the seizure-related behavior of LA and investigated the treatment with anticonvulsant drugs.
resultsThe use of LA resulted in clear changes in the ECoG pattern, which presented characteristics of Status epilepticus, with increased intensity in all brainwaves. The decomposition of the cerebral waves showed an increase in the beta and gamma waves that may be related to tonic-clonic seizure. Although the treatment with anticonvulsants drugs reduces the power of brainwaves at frequencies between 1 and 40 Hz compared to the LA group, but only diazepam (DZP) was able to decrease the intensity of oscillations. The muscle contraction power also indicated a difference in the effectiveness of the three treatments.
conclusionThe sum of the evidence indicates that LA causes status epilepticus and that DZP is the most effective treatment for the control of these seizures, by restoring the systemic values to levels close to those recorded in the control group.
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