Evidence map›Paper›PMID 33369276›Full record

Trial reportClinical pharmacology in drug development2021

Comparison of Steroidogenic Exposure Following the Administration of Repository Corticotropin Injection With a Synthetic ACTH

Xiaofeng Wang, Loan Pham, Nagaraju Poola, Leah R Brooks, Bryan Due

Open access · bronzeAbstract readClinical Trial, Phase IComparative StudyRandomized Controlled Trial
In one paragraph

Trial report in Clinical pharmacology in drug development, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 18 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. ActharClinical drug investigation · 2023
    Review
  8. Review
  9. Acthar Gel Inhibits the Activation of CD4Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2023
    Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Xiaofeng WangMallinckrodt Pharmaceuticals, Bedminster, New Jersey, USA.
Loan PhamMallinckrodt Pharmaceuticals, Bedminster, New Jersey, USA.
Nagaraju PoolaMallinckrodt Pharmaceuticals, Bedminster, New Jersey, USA.
Leah R BrooksMallinckrodt Pharmaceuticals, Bedminster, New Jersey, USA.
Bryan DueMallinckrodt Pharmaceuticals, Bedminster, New Jersey, USA.
Mallinckrodt (United States) · US

Funding

Mallinckrodt Pharmaceuticals
6 · The paper itself

Abstract

The pharmacokinetics (PK) and pharmacodynamics (PD) of clinically relevant doses of repository corticotropin injection (Acthar Gel) and synthetic ACTH

Indexed as

Models, BiologicalAdultCosyntropinDose-Response Relationship, DrugDrug Administration ScheduleFemaleGlucocorticoidsHormonesHumansHydrocortisoneMaleMethylprednisoloneYoung AdultCosyntropinGlucocorticoidsHormonesHydrocortisoneMethylprednisoloneActhar Geladrenocorticotropic hormoneglucocorticoidsmelanocortin receptorspharmacodynamicspharmacokineticsrepository corticotropin injectionsteroidogenic exposuresynthetic ACTH1-24 depot

Identifiers

PMID33369276
PMCPMC8359281
OpenAlexW3113925818

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.