ArticleCNS neuroscience & therapeutics2021
Effect of experimental orthodontic pain on gray and white matter functional connectivity.
Article in CNS neuroscience & therapeutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Research Hotspots and Emerging Trends of Orthodontic-Related Discomfort and Pain: A Bibliometric Review.Pain research & management · 2025Pooled it
- Systematic review on effects of experimental orthodontic tooth displacement on brain activation assessed by fMRI.Clinical and experimental dental research · 2024Pooled it
- Combined Functional and Structural Imaging of White Matter Reveals Brain Connectivity Alterations in Fibromyalgia Patients.Journal of pain research · 2025Article
- Improvement in post-orthodontic chronic musculoskeletal pain after local anesthetic injections in the trigeminal area: a case series.The Journal of international medical research · 2023Article
- Functional Changes of White Matter Are Related to Human Pain Sensitivity during Sustained Nociception.Bioengineering (Basel, Switzerland) · 2023Article
- Decreased ALFF and Functional Connectivity of the Thalamus in Vestibular Migraine Patients.Brain sciences · 2023Article
- Brain default mode network mediates the association between negative perfectionism and exercise dependence.Journal of behavioral addictions · 2022Article
- Increased functional connectivity of white-matter in myotonic dystrophy type 1.Frontiers in neuroscience · 2022Article
- Altered Brain Topological Property Associated With Anxiety in Experimental Orthodontic Pain.Frontiers in neuroscience · 2022Article
- Effect of experimental orthodontic pain on gray and white matter functional connectivity.CNS neuroscience & therapeutics · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimOver 90% of patients receiving orthodontic treatment experience clinically significant pain. However, little is known about the neural correlates of orthodontic pain and which has therefore been investigated in the present study of healthy subjects using an experimental paradigm.
methodsResting-state functional magnetic resonance imaging (rsfMRI) was performed in 44 healthy subjects 24 hours after an elastic separator had been introduced between the first and the second molar on the right side of the lower jaw and in 49 age- and sex-matched healthy control (HC) subjects. A K-means clustering algorithm was used to identify functional gray matter (GM) and white matter (WM) resting-state networks, and differences in functional connectivity (FC) of GM and WM between the group of subjects with experimental orthodontic pain and HC were analyzed.
resultsTwelve GM networks and 14 WM networks with high stability were identified. Compared with HC, subjects with orthodontic pain showed significantly increased FC between WM12, which includes posterior thalamic radiation and posterior cingulum bundle, and most GM networks. Besides, the WM12 network showed significant differences in FC with three GM-WM loops involving the default mode network, dorsal attention network, and salience network, respectively.
conclusionsOrthodontic pain is shown to produce an alteration of FC in networks relevant to pain processing, which may be mediated by a WM network relevant to emotion perception and cognitive processing.
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