ArticleJournal of applied clinical medical physics2021
Lower limit of iron quantification using dual-energy CT - a phantom study.
Article in Journal of applied clinical medical physics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Photon-Counting Computed Tomography-Based Hepatic iron Quantification Using a Tungsten-Based Contrast Agent.Investigative radiology · 2025Article
- Multicontrast Multiphase Intestinal Imaging Using Photon-Counting CT: A Feasibility Study in Rats.Investigative radiology · 2025Article
- Harnessing dual-energy CT for glycogen quantification: a phantom analysis.Quantitative imaging in medicine and surgery · 2023Article
- Spectral CT: Current Liver Applications.Diagnostics (Basel, Switzerland) · 2023Review
- Multiparametric Quantitative Imaging Biomarker as a Multivariate Descriptor of Health: A Roadmap.Academic radiology · 2023Review
- Quantitative dual-energy CT techniques in the abdomen.Abdominal radiology (New York) · 2022Review
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Authors and funding
3 authors.
Funding
Abstract
purposeDual-energy computed tomography (DECT) has been proposed for quantification of hepatic iron concentration (IC). However, the lower limit of quantification (LLOQ) has not been established, limiting the clinical adoption of this technology. In this study, we aim to (a) establish the LLOQ using phantoms and (b) investigate the effects of patient size, dose level, energy combination, and reconstruction method.
methodsThree phantom sizes and eight vials of ferric nitrate solution with IC ranging from 0 to 10 mg/ml were used. DECT scans were performed at 80/140 and 100/140Sn kVp, and using five different levels of CT dose index (CTDI). An image-domain three-material-decomposition algorithm was used to calculate the IC. The LLOQ was determined based on the coefficient of variation from repeated measurements.
resultsThe measured IC correlated strongly with the true IC in the small and medium phantoms (R
conclusionIron quantification at clinically important levels was achieved in a small- and a medium-sized phantom using DECT, but proved challenging in a large phantom. Wide spectral separation and accurate calibration were found to be critical to the success of the technology.
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