ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2021
The Drosophila E78 nuclear receptor regulates dietary triglyceride uptake and systemic lipid levels.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 13 citations in OpenAlex.
- Transcriptional Control of Lipid Metabolism.Advances in experimental medicine and biology · 2026Review
- Ecdysone-controlled nuclear receptor ERR regulates metabolic homeostasis in the disease vector mosquito Aedes aegypti.PLoS genetics · 2024Article
- Identification of ecdysone receptor target genes in the worker honey bee brains during foraging behavior.Scientific reports · 2023Article
- Wds-Mediated H3K4me3 Modification Regulates Lipid Synthesis and Transport inInternational journal of molecular sciences · 2023Article
- Mifepristone Increases Life Span in FemaleFrontiers in aging · 2022Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundLipid levels are maintained by balancing lipid uptake, synthesis, and mobilization. Although many studies have focused on the control of lipid synthesis and mobilization, less is known about the regulation of lipid digestion and uptake.
resultsHere we show that the Drosophila E78A nuclear receptor plays a central role in intestinal lipid homeostasis through regulation of the CG17192 digestive lipase. E78A mutant adults fail to maintain proper systemic lipid levels following eclosion, with this effect largely restricted to the intestine. Transcriptional profiling by RNA-seq revealed a candidate gene for mediating this effect, encoding the predicted adult intestinal lipase CG17192. Intestine-specific disruption of CG17192 results in reduced lipid levels similar to that seen in E78A mutants. In addition, dietary supplementation with free fatty acids, or intestine-specific expression of either E78A or CG17192, is sufficient to restore lipid levels in E78A mutant adults.
conclusionThese studies support the model that E78A is a central regulator of adult lipid homeostasis through its effects on CG17192 expression and lipid digestion. This work also provides new insights into the control of intestinal lipid uptake and demonstrate that nuclear receptors can play an important role in these pathways.
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