Evidence map›Paper›PMID 33368736›Full record

ArticleInternational journal of paediatric dentistry2021

Caregivers' report of HIV-associated oral manifestations among HIV-unexposed, exposed, and infected Kenyan children.

Ana Lucia Seminario, Arthur Kemoli, Sarah Benki-Nugent, Daisy Chebet, Lauren Gomez, Dalton Wamalwa, Grace John-Stewart, Jennifer A Slyker

Open access · greenAbstract read
In one paragraph

Article in International journal of paediatric dentistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Ana Lucia SeminarioDepartment of Pediatric Dentistry, University of Washington, Seattle, WA, USA.ORCID https://orcid.org/0000-0001-9742-136X
Arthur KemoliDepartment of Pediatric Dentistry & Orthodontics, University of Nairobi, Nairobi, Kenya.ORCID https://orcid.org/0000-0002-1965-6486
Sarah Benki-NugentDepartment of Global Health, University of Washington, Seattle, WA, USA.ORCID https://orcid.org/0000-0002-3034-8257
Daisy ChebetDepartment of Paediatrics and Child Health, University of Nairobi, Nairobi, Kenya.ORCID https://orcid.org/0000-0002-6375-602X
Lauren GomezDepartment of Global Health, University of Washington, Seattle, WA, USA.
Dalton WamalwaDepartment of Paediatrics and Child Health, University of Nairobi, Nairobi, Kenya.ORCID https://orcid.org/0000-0002-5510-462X
Grace John-StewartDepartment of Global Health, University of Washington, Seattle, WA, USA.ORCID https://orcid.org/0000-0002-4301-1573
Jennifer A SlykerDepartment of Global Health, University of Washington, Seattle, WA, USA.ORCID https://orcid.org/0000-0001-7095-8861
University of Washington · USUniversity of Nairobi · KE

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI CONNIE L CELUM · 1988 to 2026
$104.9M
Urgent Versus Post-Stabilization ART in HIV+ Children with Severe Co-infectionsR01HD023412 · NICHD · UNIVERSITY OF WASHINGTON · PI Grace C. John-Stewart, DALTON CHEKOKO WAMALWA · 1987 to 2026
$12.2M
Pediatric HIV-1 in Africa: Pathogenesis and ManagementK24HD054314 · NICHD · UNIVERSITY OF WASHINGTON · PI JOHN-STEWART, GRACE C. · 2006 to 2016
$1.2M
Impact of HIV, immune activation, and ART on child neurodevelopment in KenyaK01NS080637 · NINDS · UNIVERSITY OF WASHINGTON · PI BENKI-NUGENT, SARAH F. · 2012 to 2016
$848k
Long-term efficacy of pediatric HAARTR01TW007632 · FIC · UNIVERSITY OF NAIROBI · PI WAMALWA, DALTON CHEKOKO · 2006 to 2010
$352k
Center for AIDS Research (CFAR) New Investigator AwardFIC NIH HHS R01 TW007632Global Research Initiative Program, Social Science R01TW007632NIAID NIH HHS P30 AI027757NICHD NIH HHS K24 HD054314NICHD NIH HHS R01 HD023412NIH HHS K24 HD054314NIH HHS P30 AI027757NINDS NIH HHS K01 NS080637
6 · The paper itself

Abstract

backgroundFew oral health studies have been conducted in HIV-exposed uninfected children, who, like their HIV-infected peers, have altered immunity and perinatal drug exposures.

aimTo compare caregiver' self-report of oral diseases, hygiene practices and utilization of routine dental care, between HIV-infected (HIV), HIV-exposed uninfected (HEU), and HIV-unexposed uninfected (HUU) children in Kenya.

designThis nested cross-sectional study was conducted at the Kenyatta National Hospital, Nairobi, Kenya. Caregivers of 196 children (104 HIV-infected, 55 HEU, and 37 HUU) participated in this study. Using a validated questionnaire from the WHO and photographs of HIV-related oral lesions, we collected data on oral diseases and oral health practices.

resultsCaregivers of HIV-infected children reported at least one oral disease in their children (42%; HEU [27%]; HUU [17%; P = .008]). Oral candidiasis was the most common disease reported (HIV-infected [24%], HEU [5.5%], and HUU [2.8%; P < .05]). Baseline CD4% was associated with oral candidiasis (OR = 0.93, 95% CI: 0.88-0.98). Only 16% of children had ever visited a dentist, and most initiated brushing after 3 years of age (83%). Nearly all (98%) caregivers desired a follow-up oral examination.

conclusionsHIV infection/exposure and low CD4% were associated with increased odds of oral diseases. Most caregivers desired a follow-up oral examination for their children.

Indexed as

HIV InfectionsOral HealthCandidiasis, OralCaregiversCD4 Lymphocyte CountChildCross-Sectional StudiesFemaleHumansKenyaPregnancychildrenglobal healthHIVoral health

Identifiers

PMID33368736
PMCPMC9162147
OpenAlexW3115549707

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.