ArticleClinical transplantation2021
Evolving utilization of donation after circulatory death livers in liver transplantation: The day of DCD has come.
Article in Clinical transplantation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Normothermic Regional Perfusion in Controlled Donation After Circulatory Death Liver Transplantation: A Systematic Review and Meta-Analysis.Transplant international : official journal of the European Society for Organ Transplantation · 2024Pooled it
- Utilization and Outcomes of Septuagenarian Donation After Circulatory Death Donors.Transplantation direct · 2026Article
- A journey from marginality to routine and beyond: single center experience with DCD utilization for liver transplantation in Italy.Updates in surgery · 2026Article
- Reduction in Red Blood Cell Lysis by Polymer Intervention During Rodent Liver Normothermic Machine Perfusion.Transplantation direct · 2026Article
- Case Report:Frontiers in immunology · 2026Article
- Overcoming barriers and expanding opportunities in liver transplantation in Mexico.World journal of transplantation · 2025Review
- Development of Transplant Surgeon-Innovated Ex Vivo Machine Perfusion: Validation in a Porcine Donation after Circulatory Death-Simulated Liver Transplant Model.Yonsei medical journal · 2025Article
- Article
- Review
- Thoracoabdominal Normothermic Regional Perfusion: Real-world Experience and Outcomes of DCD Liver Transplantation.Transplantation direct · 2025Article
- Optimized partial freezing protocol enables 10-day storage of rat livers.Scientific reports · 2024Article
- Optimized Partial Freezing Protocol Enables 10-Day Storage of Rat Livers.Research square · 2024Article
- Integrated transcriptomics and histopathology approach identifies a subset of rejected donor livers with potential suitability for transplantation.BMC genomics · 2024Article
- Article
- Current Understanding of Marginal Grafts in Liver Transplantation.Aging and disease · 2024Review
- Current status of simultaneous liver-kidney transplantation.Hepatology forum · 2024Review
- Gradual rewarming with a hemoglobin-based oxygen carrier improves viability of donation after circulatory death in rat livers.Frontiers in transplantation · 2024Article
- Modern-Day Practice of DCD Liver Transplantation: Controversies, Innovations, and Future Directions.Current gastroenterology reports · 2023Review
- Selecting DCD Recipients Using Predictive Indices.Transplantation direct · 2023Article
- Beyond the Concepts of Elder and Marginal in DCD Liver Transplantation: A Prospective Observational Matched-Cohort Study in the Italian Clinical Setting.Transplant international : official journal of the European Society for Organ Transplantation · 2023Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Compared to donation after brain death (DBD), livers procured for transplantation from donation after circulatory death (DCD) donors experience more ischemia-reperfusion injury and higher rates of ischemic cholangiopathy due to the period of warm ischemic time (WIT) following withdrawal of life support. As a result, utilization of DCD livers for liver transplant (LT) has generally been limited to short WITs and younger aged donor grafts, causing many recovered DCD organs to be discarded without consideration for transplant. This study assesses how DCD liver utilization and outcomes have changed over time, using OPTN data from adult, first-time, deceased donor, whole-organ LTs between January 1995 and December 2019. Results show that increased clinical experience with DCD LT has translated into increased use of livers from DCD donors, shorter ischemic times, shorter lengths of hospitalization after transplant, and lower rates of retransplantation. The data also reveal that over the past decade, the rate of increase in DCD LTs conducted in the United States has outpaced that of DBD. Together, these trends signal an opportunity for the field of liver transplantation to mitigate the organ shortage by capitalizing on DCD liver allografts that are currently not being utilized.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.