Evidence map›Paper›PMID 33368694›Full record

ArticleJournal of veterinary internal medicine2021

Risk factors associated with disturbances of calcium homeostasis after initiation of a phosphate-restricted diet in cats with chronic kidney disease.

Pak-Kan Tang, Rebecca F Geddes, Yu-Mei Chang, Rosanne E Jepson, Esther Bijsmans, Jonathan Elliott

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary internal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Dietary phosphorus and renal disease in cats: where are we?Journal of feline medicine and surgery · 2024
    Review
  5. Article
  6. Article
  7. Article
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  9. Article
  10. Metabolomic changes in cats with renal disease and calcium oxalate uroliths.Metabolomics : Official journal of the Metabolomic Society · 2022
    Article
  11. Article
  12. Article
  13. Article
  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 3 countries.

Pak-Kan TangDepartment of Comparative Biomedical Sciences, Royal Veterinary College, University of London, London, UK.ORCID https://orcid.org/0000-0002-8244-6131
Rebecca F GeddesDepartment of Clinical Science and Services, Royal Veterinary College, University of London, London, UK.ORCID https://orcid.org/0000-0001-9216-4886
Yu-Mei ChangResearch Support Office, Royal Veterinary College, University of London, London, UK.
Rosanne E JepsonDepartment of Clinical Science and Services, Royal Veterinary College, University of London, London, UK.
Esther BijsmansResearch and Development, Royal Canin, Aimargues, France.
Jonathan ElliottDepartment of Comparative Biomedical Sciences, Royal Veterinary College, University of London, London, UK.
University of London · GBBouygues (France) · FR

Funding

Royal Canin
6 · The paper itself

Abstract

backgroundDietary phosphate restriction improves survival in cats with chronic kidney disease (CKD). However, feeding a phosphate-restricted diet may disrupt calcium homeostasis leading to hypercalcemia in some cats.

objectivesTo identify risk factors associated with increasing plasma total calcium (tCa) concentration after transition to a phosphate-restricted diet and to explore its role in CKD-mineral and bone disorder (CKD-MBD) in cats. ANIMALS: Seventy-one geriatric (≥9 years) euthyroid client-owned cats with International Renal Interest Society (IRIS) stage 2 to 3 azotemic CKD.

methodsRetrospective cross-sectional cohort study. Changes in plasma tCa concentration in the first 200 days of diet transition were assessed using linear regression. Binary logistic regressions were performed to identify risk factors for increasing calcium concentration. Changes in clinicopathological variables associated with CKD-MBD over time were explored using linear mixed model and generalized linear mixed model analyses.

resultsLower baseline plasma potassium (odds ratio [OR] = 1.19 per 0.1 mmol/L decrease; P = .003) and phosphate (OR = 1.15 per 0.1 mmol/L decrease; P = .01) concentrations remained independent risk factors for increasing plasma tCa concentration. Plasma creatinine (β = .069 ± .029 mg/dL; P = .02), symmetric dimethylarginine (β = .64 ± .29 μg/dL; P = .03), phosphate (β = .129 ± .062 mg/dL; P = .04), and ln[FGF23] (β = .103 ± .035 pg/mL; P = .004) concentrations had significantly increased rates of change in cats with increasing plasma tCa concentration over time. CONCLUSION AND CLINICAL IMPORTANCE: Lower plasma potassium or phosphate concentrations or both at the time of transition of cats with CKD to a phosphate-restricted diet are independently associated with increased risk of an increase in plasma tCa concentration. Increasing plasma tCa concentration is associated with progression of CKD.

Indexed as

Cat DiseasesRenal Insufficiency, ChronicAnimalsCalciumCatsCross-Sectional StudiesDietHomeostasisPhosphatesRetrospective StudiesRisk FactorsCalciumPhosphatesCKD-MBDfelineFGF23hypercalcemiaprogressionrenal diet

Identifiers

PMID33368694
PMCPMC7848342
OpenAlexW3116543937

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.