ArticleJournal of veterinary internal medicine2021
Clinical implications of using adrenocorticotropic hormone diagnostic cutoffs or reference intervals to diagnose pituitary pars intermedia dysfunction in mature horses.
Article in Journal of veterinary internal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 48 citations in OpenAlex.
- Preliminary evaluation of beta-endorphin alone and in combination with adrenocorticotropic hormone for the diagnosis of pituitary pars intermedia dysfunction in equids.Journal of veterinary internal medicine · 2026Article
- Assessment of baseline adrenocorticotropic hormone and insulin concentrations in healthy horses in Saskatchewan over a 1-year period.Journal of veterinary internal medicine · 2026Article
- Both Season and Equid Type Affect Endogenous Adrenocorticotropic Hormone Concentrations in Healthy Donkeys, Mules and Hinnies in the United States.Animals : an open access journal from MDPI · 2026Article
- Impact of pituitary pars intermedia dysfunction on inflammation within the equine reproductive tract of the mare.Frontiers in veterinary science · 2026Article
- Influence of Extended Photoperiod Using Blue Light Masks on Hypertrichosis, Coat Condition and General Health Parameters in Horses with Pituitary Pars Intermedia Dysfunction.Animals : an open access journal from MDPI · 2025Article
- Equine Pituitary Pars Intermedia Dysfunction.Veterinary sciences · 2025Review
- Spring and fall blood concentrations of adrenocorticotropic hormone, insulin, and thyroxine in healthy horses in Saskatchewan.The Canadian veterinary journal = La revue veterinaire canadienne · 2024Article
- Prospective Case Series of Clinical Signs and Adrenocorticotrophin (ACTH) Concentrations in Seven Horses Transitioning to Pituitary Pars Intermedia Dysfunction (PPID).Veterinary sciences · 2022Article
- Pituitary Pars Intermedia Dysfunction (PPID) in Horses.Veterinary sciences · 2022Review
- Effect of early or late blood sampling on thyrotropin releasing hormone stimulation test results in horses.Journal of veterinary internal medicine · 2022Article
- Short-Term Effects of Temperature and Thyrotropin-Releasing Hormone Stimulation on Adrenocorticotropin Stability in Horses.Animals : an open access journal from MDPI · 2022Article
- Seasonal variation of endogenous adrenocorticotropic hormone concentrations in healthy non-geriatric donkeys in Northern California.Frontiers in veterinary science · 2022Article
- Repeatability of a thyrotropin-releasing hormone stimulation test for diagnosis of pituitary pars intermedia dysfunction in mature horses.Journal of veterinary internal medicine · 2021Article
- Changes Associated with the Peri-Ovulatory Period, Age and Pregnancy in ACTH, Cortisol, Glucose and Insulin Concentrations in Mares.Animals : an open access journal from MDPI · 2021Article
- Clinical implications of using adrenocorticotropic hormone diagnostic cutoffs or reference intervals to diagnose pituitary pars intermedia dysfunction in mature horses.Journal of veterinary internal medicine · 2021Article
- The Effect of Season and Breed on Hypothalamic-Pituitary-Adrenal Axis Hormones, Metabolic Hormones, and Oxidative Markers in Ponies and Horses.Journal of veterinary internal medicineArticle
- Characterization and comparison of fecal microbiota in horses with pituitary pars intermedia dysfunction and age-matched controls.Journal of veterinary internal medicineArticle
- Evaluation of an HMGA2 variant contribution to height and basal insulin concentrations in ponies.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundDiagnosis of pituitary pars intermedia dysfunction (PPID) is problematic because of large variations in ACTH concentrations. HYPOTHESIS/
objectivesCompare the test characteristics of baseline and post-thyrotropin-releasing hormone (TRH) stimulation plasma ACTH concentrations in horses using diagnostic cutoff values (DCOVs) and reference intervals (RIs) and determine the clinical consequences of using each method. ANIMALS: One hundred six mature horses: 72 control cases and 34 PPID cases.
methodsProspective case-controlled study. Horses underwent monthly TRH stimulation tests. Diagnostic cutoff values were determined monthly by receiver operating characteristic curves using the Youden index. Reference intervals were determined monthly by a robust method. For each case age, sex and body condition score (BCS) were recorded.
resultsBaseline ACTH concentrations varied by month (P < .001) with significant "month × age" (P = .003), "month × sex" (P = .003), and "month × BCS" (P = .007) effects. Baseline ACTH concentrations were accurate to diagnose PPID (0.91 ± 0.06) with DCOVs increasing the test sensitivity (0.61 ± 0.21 to 0.87 ± 0.05, P = .002) and RI increasing test specificity (0.85 ± 0.12 to 0.98 ± 0.01, P = .01). Thyrotropin-releasing hormone stimulation improved test accuracy (0.91 ± 0.06 to 0.97 ± 0.03, P = .004). CONCLUSIONS AND CLINICAL IMPORTANCE: ACTH concentrations follow a circannual rhythm and vary with physiological factors. As using DCOVs increases the ability to detect mild cases and using RI decreases the risk of unnecessary treatments, ACTH concentrations should be interpreted within a specific clinical context. The TRH stimulation test improves the diagnosis of PPID.
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