Evidence map›Paper›PMID 33368564›Full record

ArticleJournal of pineal research2021

Mass-spectrometry analysis of the human pineal proteome during night and day and in autism.

Guillaume Dumas, Hany Goubran-Botros, Mariette Matondo, Cécile Pagan, Cyril Boulègue, Thibault Chaze, Julia Chamot-Rooke, Erik Maronde, Thomas Bourgeron

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pineal research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Guillaume DumasHuman Genetics and Cognitive Functions, Institut Pasteur, UMR 3571 CNRS, University Paris Diderot, Paris, France.ORCID https://orcid.org/0000-0002-2253-1844
Hany Goubran-BotrosHuman Genetics and Cognitive Functions, Institut Pasteur, UMR 3571 CNRS, University Paris Diderot, Paris, France.
Mariette MatondoInstitut Pasteur, Unité de Spectrométrie de Masse pour la Biologie (MSBio), Centre de Ressources et Recherches Technologiques (C2RT), USR 2000 CNRS, Paris, France.ORCID https://orcid.org/0000-0003-3958-7710
Cécile PaganParis Descartes University, Paris, France.
Cyril BoulègueInstitut Pasteur, Unité de Spectrométrie de Masse pour la Biologie (MSBio), Centre de Ressources et Recherches Technologiques (C2RT), USR 2000 CNRS, Paris, France.
Thibault ChazeInstitut Pasteur, Unité de Spectrométrie de Masse pour la Biologie (MSBio), Centre de Ressources et Recherches Technologiques (C2RT), USR 2000 CNRS, Paris, France.
Julia Chamot-RookeInstitut Pasteur, Unité de Spectrométrie de Masse pour la Biologie (MSBio), Centre de Ressources et Recherches Technologiques (C2RT), USR 2000 CNRS, Paris, France.ORCID https://orcid.org/0000-0002-9427-543X
Erik MarondeInstitute for Anatomy II, Faculty of Medicine, Goethe University, Frankfurt, Germany.ORCID https://orcid.org/0000-0002-5574-6323
Thomas BourgeronHuman Genetics and Cognitive Functions, Institut Pasteur, UMR 3571 CNRS, University Paris Diderot, Paris, France.ORCID https://orcid.org/0000-0001-8164-9220
Centre National de la Recherche Scientifique · FRDélégation Paris 5 · FRGoethe University Frankfurt · DE

Funding

Agence Nationale de la Recherche Eranet-Neuron (ALTRUISM)Agence Nationale de la Recherche Labex BioPsyAgence Nationale de la Recherche Labex GenMedAssistance Publique - Hôpitaux de ParisBettencourt-Schueller foundationCentre National de la Recherche ScientifiqueCognacq-Jay foundationConny-Maeva foundationFondaMental foundationFondation de FranceFonds de Recherche du Québec - SantéInstitute for Data Valorization (IVADO)Institut National de la Santé et de la Recherche MédicaleInstitut PasteurOrange foundationUniversité Paris Diderot
6 · The paper itself

Abstract

The human pineal gland regulates day-night dynamics of multiple physiological processes, especially through the secretion of melatonin. Using mass-spectrometry-based proteomics and dedicated analysis tools, we identify proteins in the human pineal gland and analyze systematically their variation throughout the day and compare these changes in the pineal proteome between control specimens and donors diagnosed with autism. Results reveal diverse regulated clusters of proteins with, among others, catabolic carbohydrate process and cytoplasmic membrane-bounded vesicle-related proteins differing between day and night and/or control versus autism pineal glands. These data show novel and unexpected processes happening in the human pineal gland during the day/night rhythm as well as specific differences between autism donor pineal glands and those from controls.

Indexed as

Circadian RhythmProteomeProteomicsSpectrometry, Mass, Electrospray IonizationTandem Mass SpectrometryAutistic DisorderCase-Control StudiesHumansPineal GlandProtein Interaction MapsProteinsTime FactorsProteinsProteomeantioxidantautism spectrum disorderschaperon proteinscircadian rhythmenergy productionmass spectrometrypineal gland

Identifiers

PMID33368564
PMCPMC8047921
OpenAlexW3117970031

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.