Evidence map›Paper›PMID 33368267›Full record

ArticleThe Journal of comparative neurology2021

Identification and localization of a gonadotropin-releasing hormone-related neuropeptide in Biomphalaria, an intermediate host for schistosomiasis.

Mariela Rosa-Casillas, Paola Méndez de Jesús, Laura C Vicente Rodríguez, Mohamed R Habib, Roger P Croll, Mark W Miller

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of comparative neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. A conserved gastropod withdrawal circuit inJournal of neurophysiology · 2024
    Article
  2. Article
  3. FMRF-NHThe Journal of comparative neurology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Mariela Rosa-CasillasInstitute of Neurobiology and Department of Anatomy and Neurobiology, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico.
Paola Méndez de JesúsInstitute of Neurobiology and Department of Anatomy and Neurobiology, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico.
Laura C Vicente Rodríguez
Mohamed R HabibMedical Malacology Department, Theodor Bilharz Research Institute, Giza, Egypt.
Roger P CrollDepartment of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia, Canada.ORCID 0000-0002-9846-0923
Mark W MillerInstitute of Neurobiology and Department of Anatomy and Neurobiology, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico.ORCID 0000-0002-1237-9631
University of Puerto Rico, Medical Sciences Campus · PRDalhousie University · CATheodor Bilharz Research Institute · EG

Funding

Upstream Regulation and Downstream effectors of c-MYC in Ovarian CancerU54MD007600 · NIMHD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI Carmen M Velez Vega · 2017 to 2026
$35.8M
Upgrade Laboratories Facilities at UPR-Rio PiedrasR25GM061151 · NIGMS · UNIVERSITY OF PUERTO RICO RIO PIEDRAS · PI CARBALLEIRA, NESTOR MANUEL · 2001 to 2023
$32.5M
RISE Option III: MBRS RISE at the UPR Medical Sciences CampusR25GM061838 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI CADILLA, CARMEN LYDIA · 2000 to 2021
$25.5M
The Role of Sensory Input to Mammalian Locomotion After the Loss of supraspinal.P20GM103642 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI LASALDE-DOMINICCI, JOSE ANTONIO · 2013 to 2023
$20.6M
RIO PIEDRAS MARC U*STAR DEVELOPMENT PROGRAMT34GM007821 · NIGMS · UNIVERSITY OF PUERTO RICO RIO PIEDRAS · PI CARBALLEIRA, NESTOR MANUEL · 1985 to 2020
$20.3M
TRANSLATIONAL PROTEOMICS CENTERG12MD007600 · NIMHD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI FERNANDEZ-REPOLLET, EMMA · 2012 to 2016
$11.0M
NIGMS NIH HHS GM007821NIGMS NIH HHS GM061151NIGMS NIH HHS GM103642NIGMS NIH HHS P20 GM103642NIGMS NIH HHS R25 GM061151NIGMS NIH HHS R25 GM061838NIGMS NIH HHS T34 GM007821NIMHD NIH HHS G12 MD007600NIMHD NIH HHS MD007600NIMHD NIH HHS U54 MD007600
6 · The paper itself

Abstract

Freshwater snails of the genus Biomphalaria serve as obligatory hosts for the digenetic trematode Schistosoma mansoni, the causative agent for the most widespread form of intestinal schistosomiasis. Within Biomphalaria, S. mansoni larvae multiply and transform into the cercariae form that can infect humans. Trematode development and proliferation is thought to be facilitated by modifications of host behavior and physiological processes, including a reduction of reproduction known as "parasitic castration." As neuropeptides participate in the control of reproduction across phylogeny, a neural transcriptomics approach was undertaken to identify peptides that could regulate Biomphalaria reproductive physiology. The present study identified a transcript in Biomphalaria alexandrina that encodes a peptide belonging to the gonadotropin-releasing hormone (GnRH) superfamily. The precursor and the predicted mature peptide, pQIHFTPDWGNN-NH

Indexed as

Amino Acid SequenceAnimalsBiomphalariaGonadotropin-Releasing HormoneHost-Parasite InteractionsNeuropeptidesSchistosoma mansoniSchistosomiasis mansoniGonadotropin-Releasing HormoneNeuropeptidesBiomphalaria alexandrinaBiomphalaria glabratapond snailpulmonate molluskSchistosoma mansoni

Identifiers

PMID33368267
PMCPMC8142820
OpenAlexW3118136794

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.