ArticleClinical genetics2021
A rare disease and education: Neurofibromatosis type 1 decreases educational attainment.
Article in Clinical genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Lamotrigine for cognitive deficits associated with neurofibromatosis type 1: A phase II randomized placebo-controlled trial.Developmental medicine and child neurology · 2025Trial
- Academic Achievement of Children and Adolescents with Neurofibromatosis Type 1: A Systematic Review and Meta-Analysis.Neuropsychology review · 2025Review
- Self-reported access to specialty clinics and receipt of health surveillance among U.S. patients with neurofibromatosis 1: a national survey.Orphanet journal of rare diseases · 2025Article
- Review
- Quality of life of patients with neurofibromatosis 1-Physical disability does not necessarily result in poor mental health.Frontiers in neurology · 2024Article
- The contribution of morbidity and unemployment for the reduced labor market participation of individuals with neurofibromatosis 1 in Finland.European journal of human genetics : EJHG · 2024Article
- Employment, occupation, and income in adults with neurofibromatosis 1 in Denmark: a population- and register-based cohort study.Orphanet journal of rare diseases · 2023Article
- Longitudinal association between executive function and academic achievement in children with neurofibromatosis type 1 and plexiform neurofibromas.Journal of the International Neuropsychological Society : JINS · 2023Article
- Mendelian randomization eradicates the causal relationship between educational attainment, household income, and oropharyngeal cancer.Frontiers in oncology · 2023Article
- School performance of children with neurofibromatosis 1: a nationwide population-based study.European journal of human genetics : EJHG · 2022Article
- Article
- A rare disease and education: Neurofibromatosis type 1 decreases educational attainment.Clinical genetics · 2021Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rare heritable syndromes may affect educational attainment. Here, we study education in neurofibromatosis 1 (NF1) that is associated with multifaceted medical, social and cognitive consequences. Educational attainment in the Finnish population-based cohort of 1408 individuals with verified NF1 was compared with matched controls using Cox proportional hazards model with delayed entry and competing risk for death. Moreover, models accounting for the effects of cancer at age 15-30 years, parental NF1 and developmental disorders were constructed. Overall, the attainment of secondary education was reduced in individuals with NF1 compared to controls (hazard ratio 0.83, 95%CI 0.74-0.92). History of cancer and developmental disorders were major predictors of lack of secondary education. Individuals with NF1 obtained vocational secondary education more often than general upper secondary education. Consequently, NF1 decreased the attainment of Bachelor's and Master's degrees by 46%-49% and 64%-74%, respectively. Surprisingly, the non-NF1 siblings of individuals with NF1 also had lower educational attainment than controls, irrespective of parental NF1. In conclusion, NF1 is associated with reduced educational attainment and tendency for affected individuals to obtain vocational instead of academic education. Individuals living with NF1, especially those with cancer, developmental disorders or familial NF1, need effective student counseling and learning assistance.
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Registered trials
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