Evidence map›Paper›PMID 33367954›Full record

ArticleMammalian genome : official journal of the International Mammalian Genome Society2021

Alopecia in Harlequin mutant mice is associated with reduced AIF protein levels and expression of retroviral elements.

Maik Hintze, Sebastian Griesing, Marion Michels, Birgit Blanck, Lena Wischhof, Dieter Hartmann, Daniele Bano, Thomas Franz

Open access · hybridAbstract read
In one paragraph

Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Autophagy Dysfunction: The Kernel of Hair Loss?Clinical, cosmetic and investigational dermatology · 2024
    Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Maik HintzeInstitute of Anatomy, Neuroanatomy, Medical Faculty, UKB, University of Bonn, Bonn, Germany. mhintze@uni-bonn.de.ORCID 0000-0002-1066-6346
Sebastian GriesingInstitute of Anatomy, Neuroanatomy, Medical Faculty, UKB, University of Bonn, Bonn, Germany.
Marion MichelsInstitute of Anatomy, Neuroanatomy, Medical Faculty, UKB, University of Bonn, Bonn, Germany.
Birgit BlanckInstitute of Anatomy, Neuroanatomy, Medical Faculty, UKB, University of Bonn, Bonn, Germany.
Lena WischhofGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Dieter HartmannInstitute of Anatomy, Neuroanatomy, Medical Faculty, UKB, University of Bonn, Bonn, Germany.
Daniele BanoGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Thomas FranzInstitute of Anatomy, Neuroanatomy, Medical Faculty, UKB, University of Bonn, Bonn, Germany.
University of Bonn · DEGerman Center for Neurodegenerative Diseases · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We investigated the contribution of apoptosis-inducing factor (AIF), a key regulator of mitochondrial biogenesis, in supporting hair growth. We report that pelage abnormalities developed during hair follicle (HF) morphogenesis in Harlequin (Hq) mutant mice. Fragility of the hair cortex was associated with decreased expression of genes encoding structural hair proteins, though key transcriptional regulators of HF development were expressed at normal levels. Notably, Aifm1 (R200 del) knockin males and Aifm1

Indexed as

Disease SusceptibilityGene Expression RegulationMutationAlopeciaAnimalsApoptosis Inducing FactorBiomarkersEndogenous RetrovirusesHair FollicleImmunohistochemistryMiceMice, KnockoutMorphogenesisApoptosis Inducing FactorBiomarkers

Identifiers

PMID33367954
PMCPMC7878237
OpenAlexW3117146948

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.