Evidence map›Paper›PMID 33367948›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2021

Cardiac transthyretin amyloidosis

Viktor Löfbacka, Jan Axelsson, Björn Pilebro, Ole B Suhr, Per Lindqvist, Torbjörn Sundström

Abstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Cardiac amyloidosis: From diagnosis to therapeutics breakthroughs.World journal of experimental medicine · 2026
    Review
  2. [Genes & diseases · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Viktor LöfbackaHeart Centre, Clinical Physiology, Department of Surgical and Perioperative Sciences, Umeå University, Umeå, Sweden.
Jan AxelssonRadiation Physics, Department of Radiation Sciences, Umeå University, Umeå, Sweden.
Björn PilebroHeart Centre, Cardiology, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
Ole B SuhrHeart Centre, Cardiology, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
Per LindqvistHeart Centre, Clinical Physiology, Department of Surgical and Perioperative Sciences, Umeå University, Umeå, Sweden.
Torbjörn SundströmDiagnostic Radiology, Department of Radiation Sciences, Umeå University, Umeå, Sweden. torbjorn.sundstrom@umu.se.ORCID http://orcid.org/0000-0002-9071-8993

Funding

Hjärt-Lungfonden 20160787
6 · The paper itself

Abstract

purposeHereditary transthyretin-amyloid amyloidosis (ATTRv) is an underdiagnosed condition commonly manifesting as congestive heart failure. Recently, scintigraphy utilizing DPD as a tracer was shown to identify ATTRv and wild-type ATTR cardiomyopathy. The aim of this study was to determine the value of quantified scintigraphy utilizing

methodsForty-eight patients with genetically verified ATTRv type-A fibril composition, positive

resultsStatistically significant correlations were seen in VOIs between DPD uptakes and the corresponding echocardiographic strain values. Furthermore, DPD

conclusionsIn patients with ATTRv cardiomyopathy, DPD SPECT/CT measures the amyloid distribution and provides information on cardiac amyloid load. DPD amyloid load correlates with functional cardiac parameters.

Indexed as

Organotechnetium CompoundsPrealbuminAmyloid Neuropathies, FamilialBiomarkersDiphosphonatesEchocardiographyHumansRadiopharmaceuticalsRetrospective StudiesTomography, Emission-Computed, Single-PhotonBiomarkersDiphosphonatesOrganotechnetium CompoundsPrealbuminRadiopharmaceuticalstechnetium Tc 99m 1,1-diphosphonopropane-2,3-dicarboxylic acid2D speckle tracking strain99mTc-DPD scintigraphyAmyloidosis-hereditaryCardiomyopathySPECTTransthyretin amyloidosis

Identifiers

PMID33367948
PMCPMC8113207

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.