Evidence map›Paper›PMID 33367826›Full record

ArticleThe Journal of infectious diseases2021

Intensive Care Unit-Like Care of Nonhuman Primates with Ebola Virus Disease.

Paul W Blair, Mark G Kortepeter, Lydia G Downey, Cristian S Madar, Isaac L Downs, Karen A Martins, Franco Rossi, Janice A Williams, Annie Madar, Christopher W Schellhase and 28 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors.

Paul W BlairJohns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Mark G KortepeterUniversity of Nebraska Medical Center, Omaha, Nebraska, USA.
Lydia G DowneyArmy Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.
Cristian S MadarTripler Army Medical Center, Honolulu, Hawaii, USA.
Isaac L DownsArmy Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.
Karen A MartinsArmy Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.
Franco RossiArmy Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.
Janice A WilliamsArmy Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.
Annie MadarTripler Army Medical Center, Honolulu, Hawaii, USA.
Christopher W SchellhaseArmy Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.
Jeremy J BearssArmy Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.
Xiankun ZengArmy Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.
Sina BavariEdge BioInnovation Consulting and Management, Frederick, Maryland, USA.
Veronica SolovevaArmy Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.
Jay B WellsArmy Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.
Kelly S StuthmanArmy Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.
Nicole L GarzaArmy Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.
Sean A VantongerenArmy Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.
Ginger C DonnellyArmy Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.
Jesse SteffensArmy Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.
Jennifer KalapacaArmy Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.
Perry WisemanArmy Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.
Joseph HenryArmy Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.
Shannon MarkoArmy Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.
Mark ChappellArmy Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.
Luis Lugo-RomanArmy Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.
Elliot Ramos-RiveraArmy Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.
Christian HoferArmy Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.
Eugene BlueArmy Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.
Joshua MooreArmy Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.
Jimmy FiallosArmy Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.
Darrel WetzelArmy Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.
William D PrattArmy Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.
Tami UnangstArmy Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.
Adele MillerArmy Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.
James J SolaArmy Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.
Ronald B ReislerArmy Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.
Anthony P CardileArmy Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.

Funding

RESEARCH TRAINING IN MICROBIAL DISEASEST32AI007291 · NIAID · JOHNS HOPKINS UNIVERSITY · PI JOEL N BLANKSON, Sara Elizabeth Cosgrove · 1986 to 2026
$9.1M
Research Training in Pulmonary Immunology and Allergy at MGHT32HL116275 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI David C Christiani, ANDREW D LUSTER · 2013 to 2026
$8.6M
NHLBI NIH HHS T32 HL116275NIAID NIH HHS T32 AI007291
6 · The paper itself

Abstract

backgroundEbola virus disease (EVD) supportive care strategies are largely guided by retrospective observational research. This study investigated the effect of EVD supportive care algorithms on duration of survival in a controlled nonhuman primate (NHP) model.

methodsFourteen rhesus macaques were challenged intramuscularly with a target dose of Ebola virus (1000 plaque-forming units; Kikwit). NHPs were allocated to intensive care unit (ICU)-like algorithms (n = 7), intravenous fluids plus levofloxacin (n = 2), or a control group (n = 5). The primary outcome measure was duration of survival, and secondary outcomes included changes in clinical laboratory values.

resultsDuration of survival was not significantly different between the pooled ICU-like algorithm and control groups (8.2 vs 6.9 days of survival; hazard ratio; 0.50; P = .25). Norepinephrine was effective in transiently maintaining baseline blood pressure. NHPs treated with ICU-like algorithms had delayed onset of liver and kidney injury.

conclusionsWhile an obvious survival difference was not observed with ICU-like care, clinical observations from this model may aid in EVD supportive care NHP model refinement.

Indexed as

Critical CareHemorrhagic Fever, EbolaIntensive Care UnitsAnimalsDisease Models, AnimalEbolavirusMacaca mulattaPrimatesRetrospective StudiesanimalEbola virus diseaseFiloviridaehemorrhagic feversintensive caremodelsMononegaviralesviral

Identifiers

PMID33367826
PMCPMC8366444

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.