ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2021
Outbreak of Pseudomonas aeruginosa Infections from a Contaminated Gastroscope Detected by Whole Genome Sequencing Surveillance.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 46 citations in OpenAlex.
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- Genome sequencing for prevention of health-care-associated bacterial infections.Nature reviews. Microbiology · 2026Review
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- Real-Time Genomic Surveillance for Enhanced Healthcare Outbreak Detection and Control: Clinical and Economic Impact.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Article
- Artificial intelligence enhances genomic surveillance in healthcare outbreak investigations.Infection control and hospital epidemiology · 2026Article
- Comprehensive Review of How Endoscope Channel Biofilm Differs from Hydrated and Dry Surface Biofilm and Its Implications.Endoscopy international open · 2026Review
- Methods for cost-efficient, whole genome sequencing surveillance for enhanced detection of outbreaks in a hospital setting.PloS one · 2026Article
- Methods for cost-efficient, whole genome sequencing surveillance for enhanced detection of outbreaks in a hospital setting.medRxiv : the preprint server for health sciences · 2025Article
- Artificial Intelligence in Bacterial Infections Control: A Scoping Review.Antibiotics (Basel, Switzerland) · 2025Review
- Advancing infection prevention and control through artificial intelligence: a scoping review of applications, barriers, and a decision-support checklist.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2025Article
- Genomic Surveillance for Enhanced Healthcare Outbreak Detection and Control.medRxiv : the preprint server for health sciences · 2024Article
- Real-time genomic epidemiologic investigation of a multispecies plasmid-associated hospital outbreak of NDM-5-producing Enterobacterales infections.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2024Article
- Performance of a single-use gastroscope for esophagogastroduodenoscopy: Prospective evaluation.Endoscopy international open · 2024Article
- Two Artificial Tears Outbreak-Associated Cases of Extensively Drug-Resistant Pseudomonas aeruginosa Detected Through Whole Genome Sequencing-Based Surveillance.The Journal of infectious diseases · 2024Article
- Innovative Techniques for Infection Control and Surveillance in Hospital Settings and Long-Term Care Facilities: A Scoping Review.Antibiotics (Basel, Switzerland) · 2024Article
- Prolonged bacterial carriage and hospital transmission detected by whole genome sequencing surveillance.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2024Article
- Environmental contamination of postmortem blood cultures detected by whole-genome sequencing surveillance.Infection control and hospital epidemiology · 2023Article
- Sensitivity of National Healthcare Safety Network definitions to capture healthcare-associated transmission identified by whole-genome sequencing surveillance.Infection control and hospital epidemiology · 2023Article
- Two artificial tears outbreak-associated cases of XDRmedRxiv : the preprint server for health sciences · 2023Article
- Prevalence, antibiotic resistance patterns, and biofilm formation ability ofVeterinary world · 2023Article
Corrections and comments
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Authors and funding
19 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundTraditional methods of outbreak investigations utilize reactive whole genome sequencing (WGS) to confirm or refute the outbreak. We have implemented WGS surveillance and a machine learning (ML) algorithm for the electronic health record (EHR) to retrospectively detect previously unidentified outbreaks and to determine the responsible transmission routes.
methodsWe performed WGS surveillance to identify and characterize clusters of genetically-related Pseudomonas aeruginosa infections during a 24-month period. ML of the EHR was used to identify potential transmission routes. A manual review of the EHR was performed by an infection preventionist to determine the most likely route and results were compared to the ML algorithm.
resultsWe identified a cluster of 6 genetically related P. aeruginosa cases that occurred during a 7-month period. The ML algorithm identified gastroscopy as a potential transmission route for 4 of the 6 patients. Manual EHR review confirmed gastroscopy as the most likely route for 5 patients. This transmission route was confirmed by identification of a genetically-related P. aeruginosa incidentally cultured from a gastroscope used on 4of the 5 patients. Three infections, 2 of which were blood stream infections, could have been prevented if the ML algorithm had been running in real-time.
conclusionsWGS surveillance combined with a ML algorithm of the EHR identified a previously undetected outbreak of gastroscope-associated P. aeruginosa infections. These results underscore the value of WGS surveillance and ML of the EHR for enhancing outbreak detection in hospitals and preventing serious infections.
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