ArticleThe journal of nutrition, health & aging2021
Clinical Frailty Scale and Biomarkers for Assessing Frailty in Elder Inpatients in China.
Article in The journal of nutrition, health & aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Applying the Bradford Hill Criteria to Assess the Independent Causal Roles of Aging and Medication in Frailty Progression: A Systematic Review.Drugs & aging · 2026Pooled it
- Risk factors for preoperative frailty in older patients with gastric cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Pooled it
- Inflammatory biomarkers in older adults with frailty: a systematic review and meta-analysis of cross-sectional studies.Aging clinical and experimental research · 2022Pooled it
- The effect of perioperative multimodal rehabilitation on the frailty state of older people patients with frailty gastrointestinal surgery: a randomized controlled trial.BMC geriatrics · 2025Trial
- The Mediating Role of Hypoalbuminemia in the Association Between Frailty and Poor Outcomes in Stroke Patients.Nursing open · 2026Article
- Frailty prediction in heart failure patients with acute infections: the potential role of thiazide diuretics?PloS one · 2026Article
- Fr-AGILE: validation and reliability of a multidimensional and rapid frailty assessment tool in the Turkish elderly population.Aging clinical and experimental research · 2025Article
- Analysis of alterations in the composition of the intestinal microbiota in frail older individuals.PloS one · 2025Article
- Development and validation of a biological frailty score based on CRP, haemoglobin, albumin and vitamin D within an electronic health record database in France: a cross-sectional study.BMJ public health · 2025Article
- Predictive modeling of frailty status in elderly abdominal surgery patients by preoperative quadriceps ultrasound testing.American journal of translational research · 2024Article
- Network analysis of frailty indicators in hospitalized elderly patients: unveiling the role of depression and hemoglobin as core factors.Aging clinical and experimental research · 2023Article
- Validity and Reliability of the Short Physical Performance Battery Tool in Institutionalized Spanish Older Adults.Nursing reports (Pavia, Italy) · 2023Article
- Article
- Relationship between human serum albumin and in-hospital mortality in critical care patients with chronic obstructive pulmonary disease.Frontiers in medicine · 2023Article
- Calf circumference predicts frailty in older adults: the Chinese longitudinal healthy longevity survey.BMC geriatrics · 2022Article
- Frailty in Community-Dwelling Adults Aged 40 Years and over with Type 2 Diabetes: Association with Self-Management Behaviors.International journal of environmental research and public health · 2022Article
- Natural population cohort study on long-lived adults: West China longevity and ageing procedure (WCLAP).BMJ open · 2022Article
- Frailty and Associated Factors among Chinese Centenarians.The journal of nutrition, health & aging · 2022Article
- Functional decline in hospitalized older patients with coronavirus disease 2019: a retrospective cohort study.BMC geriatrics · 2021Article
- Effect Modification by Sex of the Hemoglobin Concentration on Frailty Risk in Hospitalized Older Patients.Clinical interventions in aging · 2021Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to assess the feasibility of the Clinical Frailty Scale (CFS) and clinical biomarkers in assessing the frailty in elder inpatients in China.
designThe study was a cross-sectional study. SETTING AND
participantsThe study included 642 elder inpatients (295 females and 347 males) aged ≥65 years, from the Department of Geriatrics of Zhejiang Hospital between January 2018 and December 2019. MEASUREMENTS: All participants underwent a comprehensive geriatric assessment and blood tests. Univariate and multivariate logistic regression was used to analyze the association between risk factors and frailty.
resultsThe average age of the participants was 82.72±8.06 years (range: 65-95 years) and the prevalence of frailty was 39.1% according to the CFS. Frail participants showed significantly lower short physical performance battery (SPPB), basic activities of daily living (ADL) and instrumental activities of daily living (IADL) scores (all p<0.001), and lower hemoglobin, total protein and albumin levels (all P<0.05) than nonfrail participants. Frail participants had higher CRP, D-dimer and fibrinogen levels than nonfrail participants (all p<0.05). Univariate logistic regression analysis showed a significant association between frailty and age, comorbidity, polypharmacy, fall history, SPPB, ADL, and IADL scores, D-dimer, fibrinogen, hemoglobin, total protein and albumin levels (all P<0.05). Multivariate logistic regression analysis indicated that age (odds ratio (OR), 95% confidence interval (CI)= 1.151(1.042-1.272), P=0.006), SPPB scores (OR, 95% CI=0.901(0.601-1.350), P<0.001), and D-dimer (OR, 95% CI=4.857(2.182-6.983), P<0.001), fibrinogen (OR, 95% CI=2.665(0.977-4.254), P<0.001), hemoglobin (OR, 95% CI=0.837(0.725-0.963), P= 0.044), and albumin (OR, 95% CI=0.860 (0.776-1.188), P<0.001) levels were independently associated with frailty in all participants.
conclusionFrailty in elder inpatients in China is characterized by older age, a lower SPPB scores, higher D-dimer and fibrinogen levels and lower hemoglobin and albumin levels. Functional decline and malnutrition may be the targets of frailty interventions.
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