Evidence map›Paper›PMID 33367439›Full record

ArticleJournal of materials chemistry. B2021

A near-infrared fluorescent probe based on a hemicyanine dye with an oxazolidine switch for mitochondrial pH detection.

Wafa Mazi, Yunnan Yan, Yibin Zhang, Shuai Xia, Shulin Wan, Momoko Tajiri, Rudy L Luck, Haiying Liu

Abstract read
In one paragraph

Article in Journal of materials chemistry. B, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wafa MaziDepartment of Chemistry, Michigan Technological University, Houghton, MI 49931, USA. yibinz@mtu.edu rluck@mtu.edu mtajiri@mtu.edu hyliu@mtu.edu.
Yunnan Yan
Yibin Zhang
Shuai Xia
Shulin Wan
Momoko Tajiri
Rudy L Luck
Haiying Liu

Funding

Ratiometric Near-infrared Fluorescent Probes for Lysosomal pH in Living CellsR15GM114751 · NIGMS · MICHIGAN TECHNOLOGICAL UNIVERSITY · PI LIU, HAIYING · 2015 to 2019
$798k
NIGMS NIH HHS R15 GM114751
6 · The paper itself

Abstract

A near-infrared fluorescent probe (AH+) has been prepared by incorporating an oxazolidine switch into a near-infrared hemicyanine dye. The probe shows fast and sensitive responses to pH from an oxazolidine switch to the hemicyanine dye upon pH decreases from 10.0 to 5.0. The probe shows good photostability, low cytotoxicity, and reversible fluorescence responses to pH changes with a pKa value of 7.6. It has been successfully used to determine pH changes in mitochondria.

Indexed as

CarbocyaninesCell SurvivalDensity Functional TheoryDose-Response Relationship, DrugFluorescent DyesHeLa CellsHumansHydrogen-Ion ConcentrationMitochondriaMolecular StructureOxazolesParticle SizeSpectrometry, FluorescenceSurface PropertiesCarbocyaninesFluorescent DyesOxazolesoxazolidinetetramethylene hemicyanine

Identifiers

PMID33367439
PMCPMC7855747

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.