ArticlePlant communications2020
PIF4 and HOOKLESS1 Impinge on Common Transcriptome and Isoform Regulation in Thermomorphogenesis.
Article in Plant communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 52 citations in OpenAlex.
- Antagonistic regulation of PIF4 and HY5 activity by BBX28 regulates thermomorphogenesis.Science advances · 2026Article
- Transcription Profiling of Potato Leaves in Response to Heat Stress at Single-Cell Resolution.Plant biotechnology journal · 2026Article
- Oligomerization-competent PIF4 drives thermomorphogenesis through functional redundancy in transactivation and DNA binding.Nature communications · 2026Article
- Dynamic water relations and alternative splicing in common bean under progressive soil drought and recovery.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- CUL3Science advances · 2026Article
- PIF4-mediated thermomorphogenesis relies on its oligomerization ability, not DNA-binding or transactivation activity.Research square · 2025Article
- Article
- GCN5-related histone acetyltransferase HOOKLESS2 regulates fungal resistance and growth in tomato.The New phytologist · 2025Article
- Extranuclear function of Arabidopsis HOOKLESS1 regulates pleiotropic developmental processes in a non-cell-autonomous manner.The New phytologist · 2025Article
- The phytochrome-interacting factor genes PIF1 and PIF4 are functionally diversified due to divergence of promoters and proteins.The Plant cell · 2024Article
- Modulation of histone acetylation enables fully mechanized hybrid rice breeding.Nature plants · 2024Article
- Natural Allelic Variations ofInternational journal of molecular sciences · 2024Article
- High-throughput field phenotyping reveals that selection in breeding has affected the phenology and temperature response of wheat in the stem elongation phase.Journal of experimental botany · 2024Article
- Light controls mesophyll-specific post-transcriptional splicing of photoregulatory genes by AtPRMT5.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The origin, evolution and functional divergence of HOOKLESS1 in plants.Communications biology · 2023Article
- Light signaling-mediated growth plasticity in Arabidopsis grown under high-temperature conditions.Stress biology · 2022Review
- Comprehensive Analysis ofInternational journal of molecular sciences · 2022Article
- PHYTOCHROME-INTERACTING FACTOR 4/HEMERA-mediated thermosensory growth requires the Mediator subunit MED14.Plant physiology · 2022Article
- High temperature restricts cell division and leaf size by coordination of PIF4 and TCP4 transcription factors.Plant physiology · 2022Article
- PIFs- and COP1-HY5-mediated temperature signaling in higher plants.Stress biology · 2022Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High temperature activates the transcription factor PHYTOCHROME-INTERACTING FACTOR4 (PIF4) to stimulate auxin signaling, which causes hypocotyl elongation and leaf hyponasty (thermomorphogenesis). HOOKLESS1 (HLS1) is a recently reported positive regulator of thermomorphogenesis, but the molecular mechanisms by which HLS1 regulates thermomorphogenesis remain unknown. In this study, we initially compared PIF4- and/or HLS1-dependent differential gene expression (DEG) upon high-temperature treatment. We found that a large number of genes are coregulated by PIF4 and HLS1, especially genes involved in plant growth or defense responses. Moreover, we found that HLS1 interacts with PIF4 to form a regulatory module and that, among the HLS1-PIF4-coregulated genes, 27.7% are direct targets of PIF4. We also identified 870 differentially alternatively spliced genes (DASGs) in wild-type plants under high temperature. Interestingly, more than half of these DASG events (52.4%) are dependent on both HLS1 and PIF4, and the spliceosome-defective mutant plantsexhibit a hyposensitive response to high temperature, indicating that DASGs are required for thermomorphogenesis. Further comparative analyses showed that the HLS1/PIF4-coregulated DEGs and DASGs exhibit almost no overlap, suggesting that high temperature triggers two distinct strategies to control plant responses and thermomorphogenesis. Taken together, these results demonstrate that the HLS1-PIF4 module precisely controls both transcriptional and posttranscriptional regulation during plant thermomorphogenesis.
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