ArticleMayo Clinic proceedings. Innovations, quality & outcomes2020
The Effect of Replacing Sitting With Standing on Cardiovascular Risk Factors: A Systematic Review and Meta-analysis.
Article in Mayo Clinic proceedings. Innovations, quality & outcomes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The effect of computer prompt in breaks of sedentary behaviour among office workers: a systematic review and meta-analysis.The international journal of behavioral nutrition and physical activity · 2025Pooled it
- Impact of Sedentary Behaviors on Blood Pressure and Cardiovascular Disease: An Umbrella Review of Systematic Reviews and Meta-Analyses.Sports medicine (Auckland, N.Z.) · 2024Pooled it
- Interventions to reduce sedentary behaviour in adults with type 2 diabetes: A systematic review and meta-analysis.PloS one · 2024Pooled it
- Trial
- Effect of Active Workstations on Neurocognitive Performance and Typing Skills: A Randomized Clinical Trial.Journal of the American Heart Association · 2024Trial
- Short-Term Cardiovascular Compensatory Responses to Varying Levels of Orthostatic Stress During Active Standing in Older Adults.Journal of clinical medicine · 2025Article
- Factors associated with the serum 25-hydroxyvitamin D levels in adults.BMC nutrition · 2025Article
- Recovery pulse rate and cardiovascular function indices in young female adults following orthostasis.Journal of biological methods · 2025Article
- Device-measured stationary behaviour and cardiovascular and orthostatic circulatory disease incidence.International journal of epidemiology · 2024Article
- Physiology of sedentary behavior.Physiological reviews · 2023Review
- The role of physical activity in the regulation of body weight: The overlooked contribution of light physical activity and sedentary behaviors.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2023Review
- Are the different cut-off points for sitting time associated with excess weight in adults? A population based study in Latin America.BMC public health · 2023Article
- Habitual sedentary time and stationary time are inversely related to aerobic fitness.Sports medicine and health science · 2022Article
- Sedentary Behaviors, Physical Inactivity, and Cardiovascular Health: We Better Start Moving!Mayo Clinic proceedings. Innovations, quality & outcomes · 2020Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
objectiveTo investigate the effect of replacing sitting with standing on cardiovascular risk factors tested in clinical trials.
methodsWe searched databases from inception up to August 28, 2019, for studies examining the effect of replacing sitting with standing on fasting blood glucose, fasting insulin, and lipid levels; blood pressure; body fat mass; weight; and waist circumference in healthy adults. Differences in mean ± SD values were used for pooling the data and calculating the mean differences and CIs.
resultsThe search found 3507 abstracts. Nine clinical trials (8 randomized and 1 nonrandomized) with 877 (64.4% [n=565] women) participants met all inclusion criteria. The mean ± SD age was 45.34±5.41 years; mean follow-up was 3.81 months, and mean difference in standing time between the intervention and control groups was 1.33 hours per day. The follow-up fasting blood glucose and body fat mass values were slightly but significantly lower than baseline records in the intervention groups compared with control groups (-2.53; 95% CI, -4.27 to -0.79 mg/dL; and -0.75; 95% CI, -0.91 to -0.59 kg). The analysis for fasting insulin levels, lipid levels, blood pressure, weight, and waist circumference revealed no significant differences.
conclusionReplacing sitting with standing can result in very small but statistically significant decreases in fasting blood glucose levels and body fat mass with no significant effect on lipid levels, blood pressure, weight, and waist circumference. Replacing sitting with standing can be used as an adjunctive intervention to decrease the burden of cardiovascular risk factors but cannot be used as an alternative to physical activity to decrease sedentary time.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.