ArticleJournal of veterinary research2020
Serum Metabolomic Analysis of Feline Mammary Carcinomas based on LC-MS and MRM Techniques.
Article in Journal of veterinary research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 8 citations in OpenAlex.
- Serum untargeted metabolomics reveals key pathways in feline mammary carcinoma for comparative oncology.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Implementation of Machine Learning-Based System for Early Diagnosis of Feline Mammary Carcinomas through Blood Metabolite Profiling.Metabolites · 2024Article
- Plasma metabolomics identifies metabolic alterations associated with the growth and development of cat.Animal models and experimental medicine · 2023Article
- Omics Technologies in Veterinary Medicine: Literature Review and Perspectives in Transfusion Medicine.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2023Review
- Article
- Correlation between metabolomic profile constituents and feline pancreatic lipase immunoreactivity.Journal of veterinary internal medicine · 2022Article
- The Serum and Fecal Metabolomic Profiles of Growing Kittens Treated with Amoxicillin/Clavulanic Acid or Doxycycline.Animals : an open access journal from MDPI · 2022Article
- Untargeted Metabolic Profiling of Cat Urine and Plasma in Hypertension.Journal of veterinary internal medicineArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionTo date, there have been no panoramic studies of the serum metabolome in feline mammary carcinoma. As the first such study, metabolomics techniques were used to analyse the serum of cats with these tumours. Three important metabolic pathways of screened differential metabolites closely related to feline mammary carcinomas were analysed to lay a theoretical basis for further study of the pathogenesis of these carcinomas. MATERIAL AND
methodsBlood in a 5-8 mL volume was sampled from twelve cats of the same breed and similar age (close to nine years on average). Six were feline mammary carcinoma patients and six were healthy. L glutamate, L alanine, succinate, adenine, hypoxanthine, and inosine were screened as were alanine, aspartate, and glutamate metabolism, the tricarboxylid acid (TCA) cycle, and purine metabolism. Data were acquired with LC-MS non-target metabolomics, multiple reaction monitoring target metabolomics, and multivariate statistical and bioinformatic analysis.
resultsExpression of five of the metabolites was upregulated and only inosine expression was downregulated. Up- and downregulation of metabolites related to glycometabolism, potentiation of the TCA cycle, greater content of lipid mobilisation metabolites, and abnormality of amino acid metabolism were closely related to the occurrence of the carcinomas.
conclusionThese findings provide a new direction for further study of the mechanisms associated with cat mammary neoplasms.
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