ArticlePractical laboratory medicine2021
Biomarker of urinary 5-HIAA as a valuable predictor of acute appendicitis.
Article in Practical laboratory medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Salivary Biomarkers in Pediatric Acute Appendicitis: Current Evidence and Future Directions.Children (Basel, Switzerland) · 2025Review
- Urinary 5-HIAA as a Potential Diagnostic Marker in Acute Appendicitis: A Preliminary Report of Its Promising Role in Early Detection.Medicina (Kaunas, Lithuania) · 2025Article
- The diagnostic utility of urinary 5-HIAA and leucine-rich alpha-2 glycoprotein in acute appendicitis: a narrative review.Frontiers in medicine · 2025Review
- 5-Hydroxyindoleacetic acid as a biomarker for revealing perforation in acute appendicitis.BMC gastroenterology · 2024Article
- Utility of Ischemia-Modified Albumin as a Biomarker for Acute Appendicitis: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2023Review
- Prediction of Perforated and Nonperforated Acute Appendicitis Using Machine Learning-Based Explainable Artificial Intelligence.Diagnostics (Basel, Switzerland) · 2023Article
- Application and curative effect of laparoscopic purse-string sutures in the treatment of adult acute complicated appendicitis.BMC surgery · 2023Article
- Comparison of the prevalence of perforated appendicitis during and before COVID19 pandemic.Annals of medicine and surgery (2012) · 2022Article
- Hemodynamic stability during menstrual cycle in women undergoing elective surgery.Annals of medicine and surgery (2012) · 2022Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSerotonin-containing cells are abundantly found in the appendix. Studies have shown that acute appendicitis is likely to be characterized by altered urinary 5-hydroxyindole acetic acid (5-HIAA), an active serotonin metabolite. The aim of this study is to investigate the diagnostic potential of 5-HIAA as a biomarker for acute appendicitis.
methodThis cross-sectional study enrolled patients referred at the Madani Hospital, with right iliac fossa pain, suspected to having the acute appendicitis. Before the initiation of the basic treatment and surgery, urine samples were obtained from the patients. Enzyme-linked immunosorbent assay (ELISA) was used for the analysis of 5-HIAA urinary levels. The obtained data were statistically analyzed using SPSS v18.
resultsOf 129 patients included in the study with the mean age of 29 years, 62 (48.1%) were men and 67 (51.9%) were women. Appendectomy was performed in 96 patients, where 81 cases were that of acute appendicitis. The mean levels of 5-HIAA in acute appendicitis group and in the negative appendectomy group was not statistically significant. The sensitivity of the test was 54.3% based on 7.4 μmol/L as cut-off %-HIAA value.
conclusionOur study reports that 5-HIAA urine concentration is not a reliable diagnostic marker for the diagnosis of acute appendicitis.
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