Evidence map›Paper›PMID 33365034›Full record

ReviewFrontiers in immunology2020

Key Metabolic Pathways in MSC-Mediated Immunomodulation: Implications for the Prophylaxis and Treatment of Graft Versus Host Disease.

Andre J Burnham, Elisabetta Manuela Foppiani, Edwin M Horwitz

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Hematopoietic stem cell metabolism within the bone marrow niche - insights and opportunities.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Tafazzin deficiency in mouse mesenchymal stem cells promote reprogramming of activated B lymphocytes toward immunosuppressive phenotypes.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022
    Article
  12. Metabolic Reconfiguration Activates Stemness and Immunomodulation of PDLSCs.International journal of molecular sciences · 2022
    Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Andre J BurnhamAflac Cancer & Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, United States.
Elisabetta Manuela FoppianiAflac Cancer & Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, United States.
Edwin M HorwitzAflac Cancer & Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, United States.
Emory University · USAflac (United States) · US

Funding

Mechanism of Interferon Gamma Primed Mesenchymal Stromal Cell Efferocytosis of Activated T CellsR56HL147867 · NHLBI · EMORY UNIVERSITY · PI HORWITZ, EDWIN M · 2019 to 2019
$390k
NHLBI NIH HHS R56 HL147867
6 · The paper itself

Abstract

Mesenchymal stromal cells (MSCs) are spindle-shaped, plastic-adherent cells

Indexed as

AnimalsGraft vs Host DiseaseHumansImmunomodulationMesenchymal Stem CellsMetabolic Networks and Pathwaysaerobic glycolysisgraft versus host diseaseheme oxygenase-1hypoxia-inducible factor 1 αindoleamine 2,3-dioxygenasekynureninemesenchymal stromal cellPGE2

Identifiers

PMID33365034
PMCPMC7750397
OpenAlexW3113175668

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.