Evidence map›Paper›PMID 33364529›Full record

ReviewBioactive materials2021

Poly(α-l-lysine)-based nanomaterials for versatile biomedical applications: Current advances and perspectives.

Maochao Zheng, Miao Pan, Wancong Zhang, Huanchang Lin, Shenlang Wu, Chao Lu, Shijie Tang, Daojun Liu, Jianfeng Cai

Abstract readReview
In one paragraph

Review in Bioactive materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed.

  1. Article
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  6. Review
  7. Charge-Shifting Copolymers of 2‑(ACS applied polymer materials · 2026
    Article
  8. Article
  9. Effect ofInternational journal of biomaterials · 2026
    Article
  10. Article
  11. Review
  12. Review
  13. Emerging dendrimer-based RNA delivery strategies.Nanomedicine (London, England) · 2025
    Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Biomacromolecules · 2025
    Review
  19. Article
  20. TheBiomaterial investigations in dentistry · 2025
    Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Maochao ZhengShantou University Medical College, 22 Xinling Road, Shantou, 515041, China.
Miao PanShantou University Medical College, 22 Xinling Road, Shantou, 515041, China.
Wancong ZhangThe Second Affiliated Hospital of Shantou University Medical College, 69 Dongxiabei Road, Shantou, 515041, China.
Huanchang LinShantou University Medical College, 22 Xinling Road, Shantou, 515041, China.
Shenlang WuShantou University Medical College, 22 Xinling Road, Shantou, 515041, China.
Chao LuCollege of Pharmacy, Jinan University, Guangzhou, 511443, China.
Shijie TangThe Second Affiliated Hospital of Shantou University Medical College, 69 Dongxiabei Road, Shantou, 515041, China.
Daojun LiuShantou University Medical College, 22 Xinling Road, Shantou, 515041, China.
Jianfeng CaiDepartment of Chemistry, University of South Florida, Tampa, FL, 33620, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Poly(α-l-lysine) (PLL) is a class of water-soluble, cationic biopolymer composed of α-l-lysine structural units. The previous decade witnessed tremendous progress in the synthesis and biomedical applications of PLL and its composites. PLL-based polymers and copolymers, till date, have been extensively explored in the contexts such as antibacterial agents, gene/drug/protein delivery systems, bio-sensing, bio-imaging, and tissue engineering. This review aims to summarize the recent advances in PLL-based nanomaterials in these biomedical fields over the last decade. The review first describes the synthesis of PLL and its derivatives, followed by the main text of their recent biomedical applications and translational studies. Finally, the challenges and perspectives of PLL-based nanomaterials in biomedical fields are addressed.

Indexed as

Antimicrobial agentsBio-imagingBio-sensingDelivery systemsPoly(α-l-lysine)

Identifiers

PMID33364529
PMCPMC7744653

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.