ArticleJournal of biomedical physics & engineering2020
The Increment of Genoprotective Effect of Melatonin due to "Autooptic" Effect versus the Genotoxicity of Mitoxantrone.
Article in Journal of biomedical physics & engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 2 citations in OpenAlex.
- lncRNA cytoskeleton regulator reduces non‑small cell lung cancer radiosensitivity by downregulating miRNA‑206 and activating prothymosin α.International journal of oncology · 2021Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMitoxantrone is a chemotherapy anti-cancer drug, which can have side effects on healthy cells like secondary cancers. On the other side, Melatonin is a hormone that is responsible for the daily rhythm adjustment and has several properties to be anticancer and anti-inflammatory. Recently, it has been shown that all living cells produce ultraweak photon emission (UPE) spontaneously and continuously. The intensity of UPE is in the order of a few, up to 10
objectiveHere, we investigate the effect of UPE among similar cells (i.e. "Autooptic effect") by using mirrors around the cell plate(s). MATERIAL AND
methodsIn this experimental research, the HepG2 cells were co-treated by melatonin as a genoprotective and silver nanoparticles as a carrier against mitoxantrone's genotoxicity. Our results are analyzed based on the Comet assay method, and the genoprotective effect of melatonin is investigated in presence of (and without) mirrors against the genotoxicity of mitoxantrone. Additionally, the autooptic effect is investigated in presence of Ag nanoparticles (NPs).
resultsThe results indicated that Ag NPs with lower concentrations of melatonin made more protection as genoprotective agent, and the same results obtained by increasing access' cells to drug.
conclusionThe autooptic effect could increase the genoprotective effect of melatonin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.