Evidence map›Paper›PMID 33364208›Full record

ArticleJournal of biomedical physics & engineering2020

Radioprotective Effects of Zinc and Selenium on Mice Spermatogenesis.

Bagheri H, Salajegheh A, Javadi A, Amini P, Shekarchi B, Shabeeb D, Eleojo Musa A, Najafi M

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomedical physics & engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05222841 (The Effectiveness of the Spermotrend Food Supplement in the Treatment of Male Infertility and Benign Prostatic Hyperplasia), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05222841 phase2 / phase3completednot on this mapstarted 2021, after this paper: background citation

The Effectiveness of the Spermotrend Food Supplement in the Treatment of Male Infertility and Benign Prostatic Hyperplasia

TypeinterventionalSponsorCatalysis SLRan2021 to 2022Enrolled150ConditionsMale Infertility, Benign Prostatic Hyperplasia, Spermatogenesis and Semen DisordersArmsSpermotrend
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Bagheri HMSc, Radiation and Wave Research Center, Aja University of Medical Sciences, Tehran, Iran.
Salajegheh AMSc, Radiation and Wave Research Center, Aja University of Medical Sciences, Tehran, Iran.
Javadi AMD, Department of Pathology, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Amini PMSc, Department of Radiology, Faculty of Paramedical, Tehran University of Medical Sciences, Tehran, Iran.
Shekarchi BMD, Radiation and Wave Research Center, Aja University of Medical Sciences, Tehran, Iran.
Shabeeb DPhD, Department of Physiology, College of Medicine, University of Misan, Misan, Iraq.
Eleojo Musa AMSc, Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences (International Campus), Tehran, Iran.
Najafi MPhD, Medical Technology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Aja University of Medical Sciences · IRTehran University of Medical Sciences · IRKermanshah University of Medical Sciences · IRShahid Beheshti University of Medical Sciences · IRUniversity of Misan · IQ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSpermatogenesis system is one of the most radiosensitive organs in the body. A usual therapeutic dose of radiation such as the conventional 2 Gy in each fraction of radiotherapy and lower doses seen in diagnostic radiology or a radiation disaster affect the process of spermatogenesis potently. Selenium and zinc are two important elements playing key roles in the development of sperms and also have radioprotective effects.

objectiveIn this study aims to evaluate the radioprotective effect of zinc and selenium against radiation-induced mice testis injury. MATERIAL AND

methodsIn this experimental study, 30 mice were divided equally into 6 groups, including control selenium treated, zinc treated, radiation, radiation + selenium, radiation + zinc. Treatments started from 2 days before irradiation with 2 Gy cobalt-60 gamma rays. After 37 days, all mice were killed for histopathological evaluations.

resultsResults showed that exposure to radiation caused a potent effect on spermatogenesis system. Treatment with selenium reversed these radiation effects potently, while zinc had some limited protective effects. Zinc treatment itself caused a detrimental effect on epididymis and, in combination with radiation, it leads to more damage to seminiferous tubules.

conclusionIn contrast to previous studies that proposed zinc to protect spermatogenesis against various toxic agents, results of this study showed that although zinc may protect from some parameters, it potentiates radiation damage on seminiferous tubules and has a detrimental effect on the epididymis. By contrast, zinc and selenium could alleviate radiation-induced toxicity on the most of the evaluated parameters.

Indexed as

EpididymisRadiationSeleniumSeminiferous TubulesSpermatogenesisZinc

Identifiers

PMID33364208
PMCPMC7753255
OpenAlexW2965214676

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.