ReviewCureus2020
Similarities Between Depression and Neurodegenerative Diseases: Pathophysiology, Challenges in Diagnosis and Treatment Options.
Review in Cureus, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Disruptive resting state networks characterizing depressive comorbidity in Alzheimer's disease and mild cognitive impairment.Journal of Alzheimer's disease : JAD · 2025Pooled it
- Unveiling discrepancies in depression detection among persons with dementia: A comparative analysis of caregiver and self-report.Journal of Alzheimer's disease : JAD · 2026Article
- Herbal and Herbomineral Preparation in Neurodegenerative Disorder.Annals of African medicine · 2026Review
- Toward Safer Diagnoses: A SEIPS-Based Narrative Review of Diagnostic Errors.Diagnostics (Basel, Switzerland) · 2026Review
- Mapping Global Trends and Research Hotspots in Postoperative Depression: A Bibliometric Analysis.Behavioural neurology · 2026Article
- Clinical practice guideline for assessment and management of depression in India.Indian journal of psychiatry · 2026Article
- The dual role of ACE2 in viral infections and neurodegeneration: mechanisms and therapeutic opportunities.Journal of neurovirology · 2025Review
- Evaluating the Serum Level of ACTH and Investigating the Expression of miR-26a, miR-34a, miR-155-5p, and miR-146a in the Peripheral Blood Cells of Multiple Sclerosis Patients.Biochemical genetics · 2025Article
- HIITing Anxiety and Depression in Parkinson's Disease and Multiple Sclerosis-A Study Protocol of a Transdiagnostic Randomized Controlled Trial (HersenFIT).Brain sciences · 2025Article
- Application of machine learning and temporal response function modeling of EEG data for differential diagnosis in primary progressive aphasia.Scientific reports · 2025Article
- Prevalence and Correlates of Depressive Symptoms and Cognitive Impairment in Elderly People over 65 Years Old in the Community and Nursing Homes.Alpha psychiatry · 2025Article
- The Role of Inflammation in Depression and Beyond: A Primer for Clinicians.Current psychiatry reports · 2024Review
- Neurodegeneration in Cognitive Impairment and Mood Disorders for Experimental, Clinical and Translational Neuropsychiatry.Biomedicines · 2024Article
- Neuroinflammation in comorbid depression in Alzheimer's disease: A pilot study using post-mortem brain tissue.Neuroscience applied · 2024Article
- The utility of PET imaging in depression.Frontiers in psychiatry · 2024Review
- Trace Elements Levels in Major Depressive Disorder-Evaluation of Potential Threats and Possible Therapeutic Approaches.International journal of molecular sciences · 2023Review
- Identification and Experimental Validation of Parkinson's Disease with Major Depressive Disorder Common Genes.Molecular neurobiology · 2023Article
- CASP3 gene expression and the role of caspase 3 in the pathogenesis of depressive disorders.BMC psychiatry · 2023Article
- Artificial Intelligence: Deciphering the Links between Psychiatric Disorders and Neurodegenerative Disease.Brain sciences · 2023Article
- Synthesis and Biological Evaluation ofAntioxidants (Basel, Switzerland) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Depressive disorder and neurodegenerative diseases are two different clinical entities. Depression is a common psychiatric disorder in the general population. However, when present concomitantly with neurodegenerative disorders, its diagnosis becomes challenging. In many cases, patients remain undiagnosed and hence, untreated, worsening the prognosis of the neurodegenerative diseases and impairing the quality of life. One of the possible reasons for the difficulties in diagnosis in such cases is that both conditions affect the central nervous system, so there might be an overlap of symptoms leading to a missed diagnosis of depression in a neurodegenerative disease patient and vice versa. Symptoms such as irritability, apathy, and decreased cognition are common to both types of disorders. Some neurodegenerative diseases, especially Alzheimer's disease, can initially present as a depressive prodrome. This may cause a difficulty in differentiating between these two conditions and a diagnosis of either conditions may be missed; hence an opportunity for timely intervention and improved outcomes is missed. An approach towards analyzing and comparing the pathological mechanisms common to both disease types will create a better understanding of depression and neurodegenerative diseases, identify their similarities, and develop improved clinical criteria to help clinicians make a timely diagnosis of these conditions present together. In the present review, various studies related to common pathological links, concomitant diagnosis challenges, and ongoing research about different treatment options are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.