ArticleCureus2020
Dengue Fever: Prognostic Insights From a Complete Blood Count.
Article in Cureus, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Study on changes in a subset of full blood count parameters of patients with dengue fever and dengue haemorrhagic fever presented to teaching hospital - Kurunegala, Sri Lanka - a descriptive cross-sectional study.BMC infectious diseases · 2025Article
- Clinico-genomic study reveals association of dengue virus genome high frequency mutations with dengue disease severity.Scientific reports · 2025Article
- Clinical characteristics and serotype association of dengue and dengue like illness in Pakistan.PLoS neglected tropical diseases · 2025Article
- Machine learning-based mathematical equations for dengue positivity detection using elementary laboratory parameters.Journal of family medicine and primary care · 2025Article
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- Dengue virus infection: how platelet-leukocyte crosstalk shapes thrombotic events and inflammation.Molecular biology reports · 2025Review
- Dengue in patients with kidney transplant: a systematic review.Le infezioni in medicina · 2025Review
- Unmasking Hepatitis A: A Case Study of Atypical Presentation in a Returning Traveler From Egypt.Case reports in hepatology · 2025Article
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- Reduced protein-coding transcript diversity in severe dengue emphasises the role of alternative splicing.Life science alliance · 2024Article
- Immuno-Haematologic Aspects of Dengue Infection: Biologic Insights and Clinical Implications.Viruses · 2024Review
- Changes in the Liver Function and Hematological Parameters in Dengue Patients at a Tertiary Care Center: A Descriptive Cross-sectional Study.JNMA; journal of the Nepal Medical Association · 2024Article
- Support Vector Machine Outperforms Other Machine Learning Models in Early Diagnosis of Dengue Using Routine Clinical Data.Advances in virology · 2024Article
- Early transcriptomic host response signatures in the serum of dengue patients provides insights into clinical pathogenesis and disease severity.Scientific reports · 2023Article
- Laboratory Findings in Patients with Probable Dengue Diagnosis from an Endemic Area in Colombia in 2018.Viruses · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction Dengue fever is endemic in more than 100 countries. Early indicators of prognosis are vital to reduce the fatality rate associated with dengue fever. The objective of this study is to investigate the value of a complete blood count (CBC) in determining the prognosis of dengue fever. Methodology This was a retrospective study of all patients admitted to Chigateri General and Bapuji hospitals, Davangere over two months. Fifty-six patients were included in the study. Medical records were accessed to obtain data on the clinical profile and laboratory investigations. Results Thrombocytopenia was the most common hematological feature, in 50 cases (~90%), followed by leukopenia in 43 cases (~76%). The duration of hospital stay ranged from two to seven days. Interestingly, the percentage of lymphocytes in the differential leukocyte count at the time of admission showed a significant negative correlation with the duration of hospital stay (p=0.028). Also, three distinct trends were observed in the sequence of recovery of platelets and white blood cells (WBCs). Discussion A repertoire of prognostic indicators have been described to predict the course and outcome of dengue fever: liver enzymes, interleukins 4 and 10, tumor necrosis factor α (TNFα), some proteases, soluble adhesion molecules, the surface area of atypical lymphocytes, high fluorescent lymphocyte counts, immature granulocytes and immature platelet factor (IPF). However, these markers are not routinely employed due to financial constraints and lack of infrastructure. The percentage of lymphocytes in the differential leukocyte count performed at the time of admission predicted the length of hospital stay. The higher the percentage of lymphocytes, the faster the recovery from dengue and shorter the duration of stay in the hospital. This is particularly important in remote areas with limited laboratory facilities. High-risk patients can be referred to a higher centre before they develop complications of the disease. Conclusion The complete blood count can function as an early indicator of prognosis in dengue fever even in areas where sophisticated biomedical infrastructure is lacking. The lymphocyte percentage on admission could significantly predict the length of hospital stay.
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