Evidence map›Paper›PMID 33364060›Full record

ArticleJournal of advanced research2021

Mechanophysiological analysis of anorectal function using simulated feces in human subjects.

Daming Sun, Donghua Liao, Ssu Chi Chen, Cherry Wong, Wing Wah Leung, Kaori Futaba, Tony Mak, Simon Ng, Hans Gregersen

Open access · goldAbstract read
In one paragraph

Article in Journal of advanced research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 16 citations in OpenAlex.

  1. Observational
  2. Article
  3. Article
  4. Review
  5. Consistency of Feces Affects Defecatory Function.Journal of neurogastroenterology and motility · 2024
    Article
  6. Fecobionics in proctology: review and perspectives.Surgery open digestive advance · 2023
    Article
  7. Article
  8. Reproducibility of the anorectal angle with transperineal ultrasound.Quantitative imaging in medicine and surgery · 2023
    Article
  9. Article
  10. Article
  11. Article
  12. Observational
  13. Article
  14. Article
  15. Novel Bionics Assessment of Anorectal Mechanosensory Physiology.Bioengineering (Basel, Switzerland) · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Daming SunSchool of Microelectronics and Communication Engineering, Chongqing University, Shapingba, Chongqing, 400044, China.
Donghua LiaoMech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Denmark.
Ssu Chi ChenDepartment of Surgery, Clinical Sciences Bldg., Prince of Wales Hospital, Shatin, Hong Kong.
Cherry WongDepartment of Surgery, Clinical Sciences Bldg., Prince of Wales Hospital, Shatin, Hong Kong.
Wing Wah LeungDepartment of Surgery, Clinical Sciences Bldg., Prince of Wales Hospital, Shatin, Hong Kong.
Kaori FutabaDepartment of Surgery, Clinical Sciences Bldg., Prince of Wales Hospital, Shatin, Hong Kong.
Tony MakDepartment of Surgery, Clinical Sciences Bldg., Prince of Wales Hospital, Shatin, Hong Kong.
Simon NgDepartment of Surgery, Clinical Sciences Bldg., Prince of Wales Hospital, Shatin, Hong Kong.
Hans GregersenDepartment of Surgery, Clinical Sciences Bldg., Prince of Wales Hospital, Shatin, Hong Kong.
Prince of Wales Hospital · CNAarhus University · DKCalifornia Medical Innovations Institute · USChongqing University · CN

Funding

Fecobionics device for mapping colonic and anorectal neuromuscular functionOT2OD025308 · OD · CALIFORNIA MEDICAL INNOVATIONS INSTITUTE · PI GREGERSEN, HANS, KASSAB, GHASSAN S · 2017 to 2020
$3.6M
NIH HHS OT2 OD025308
6 · The paper itself

Abstract

introductionDefecation is a complex process that is difficult to study and analyze.

objectivesHere, we present new analytical tools to calculate frictional force and tension during expulsion of the Fecobionics simulated stool in human subjects.

methodsThe 12-cm-long Fecobionics device contained pressure sensors, motion processor units for measurement of orientation and bending, and impedance rings for measurement of cross-sectional areas. Eight normal subjects defecated Fecobionics. The bending angle of the device, frictional force between the device and the surrounding tissue, and the stretch tensions were calculated.

resultsThe bending angle and pressures changed during expulsion with the maximum pressure recorded at the rear. The averaged circumferential tension, longitudinal tension and friction force in each subject were associated with the front-rear pressure difference (r > 0.7, p < 0.005). The peak circumferential tension, longitudinal tension, and friction force immediately before expulsion of the rear were significantly higher compared to when the front entered the anal canal (F = 164.7, p < 0.005; F = 152.1, p < 0.005; F = 71.4, p < 0.005; respectively.).

conclusionThis study shows that Fecobionics obtained reliable data under physiological conditions. Mechanical features such as frictional force and stretch tensions were assessable during Fecobionics expulsion.

Indexed as

Anorectal physiologyExpulsionFecobionicsFriction forceTension

Identifiers

PMID33364060
PMCPMC7753961
OpenAlexW3041747291

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.