Evidence map›Paper›PMID 33364048›Full record

ReviewJournal of advanced research2021

Role of pyroptosis in spinal cord injury and its therapeutic implications.

Abdullah Al Mamun, Yanqing Wu, Ilma Monalisa, Chang Jia, Kailiang Zhou, Fahad Munir, Jian Xiao

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of advanced research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
118citing papers in PubMed, 1 pooled it
9.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

118 citing papers in PubMed, 1 synthesis or guideline pooled it, 236 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Role of pyroptosis in melanoma: Molecular mechanisms and therapeutic potentials.Apoptosis : an international journal on programmed cell death · 2026
    Review
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58 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Abdullah Al MamunMolecular Pharmacology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035 Zhejiang Province, China.
Yanqing WuInstitute of Life Sciences, Wenzhou University, Wenzhou, 325035 Zhejiang Province, China.
Ilma MonalisaDepartment of Pharmacy, Southeast University, Banani, Dhaka 1213, Bangladesh.
Chang JiaPediatric Research Institute, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027 Zhejiang Province, China.
Kailiang ZhouDepartment of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027 Zhejiang Province, China.
Fahad MunirDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000 Zhejiang Province, China.
Jian XiaoMolecular Pharmacology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035 Zhejiang Province, China.
Wenzhou Medical University · CNSoutheast University · BDWenzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCurrently, spinal cord injury (SCI) is a pathological incident that triggers several neuropathological conditions, leading to the initiation of neuronal damage with several pro-inflammatory mediators' release. However, pyroptosis is recognized as a new programmed cell death mechanism regulated by the stimulation of caspase-1 and/or caspase-11/-4/-5 signaling pathways with a series of inflammatory responses.

aimOur current review concisely summarizes the potential role of pyroptosis-regulated programmed cell death in SCI, according to several molecular and pathophysiological mechanisms. This review also highlights the targeting of pyroptosis signaling pathways and inflammasome components and its therapeutic implications for the treatment of SCI. KEY SCIENTIFIC CONCEPTS: Multiple pieces of evidence have illustrated that pyroptosis plays significant roles in cell swelling, plasma membrane lysis, chromatin fragmentation and intracellular pro-inflammatory factors including IL-18 and IL-1β release. In addition, pyroptosis is directly mediated by the recently discovered family of pore-forming protein known as GSDMD. Current investigations have documented that pyroptosis-regulated cell death plays a critical role in the pathogenesis of multiple neurological disorders as well as SCI. Our narrative article suggests that inhibiting the pyroptosis-regulated cell death and inflammasome components could be a promising therapeutic approach for the treatment of SCI in the near future.

Indexed as

AIM2, Absent in melanoma 2ASC, apoptosis-associated speck-like proteinATP, Adenosine triphosphateBBG, Brilliant blue GCaspase-1CCK-8, Cell Counting Kit-8CNS, central nervous systemCO, Carbon monoxideCORM-3, Carbon monoxide releasing molecle-3Cx43, Connexin 43DAMPs, Damage-associated molecular patternsdouble stranded DNAIR, Ischemia reperfusionDRD1, Dopamine Receptor D1ECH, EchinacosideGal-3, Galectin-3GSDMD, Gasdermin DH2O2, Hydrogen peroxideHO-1, Heme oxygenase-1IL-18, Interleukin-18IL-1β, Interleukin-1 betaIRE1, Inositol requiring enzyme 1JOA, Japanese orthopedics associationLPS, LipopolysaccharideNDI, Neck data indexNeuroinflammationNF-κB, Nuclear factor-kappa BNLRP1b, NOD-like receptor protein 1bNLRP1, NOD-like receptor protein 1NLRP3NLRP3, Nucleotide-binding domain-like receptor protein 3Nrf2, Nuclear factor erythroid 2-related factor 2OPCs, Oligodendrocyte progenitor cellsPAMPs, Pathogen-associated molecular patternsPRRs, Pattern recognition receptorsPyroptosisROS, Reactive oxygen speciessi-RNA, Small interfering RNASpinal cord injuryTherapeutic implicationsTLR4, Toll-like receptor 4TXNIP, Thioredoxin-interacting protein

Identifiers

PMID33364048
PMCPMC7753222
OpenAlexW3058784328

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.