Evidence map›Paper›PMID 33363890›Full record

ArticleClinical case reports2020

A case report of a drug-induced liver injury (DILI) caused by multiple antidepressants with causality established by the updated Roussel Uclaf causality assessment method (RUCAM) and in vitro testing.

Miguel González-Muñoz, Jaime Monserrat Villatoro, Eva Marín-Serrano, Stefan Stewart, Belén Bardón Rivera, Jesús Marín, Lucía Martínez de Soto, Enrique Seco Meseguer, Elena Ramírez

Open access · goldAbstract readCase Reports
In one paragraph

Article in Clinical case reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

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  9. Antipsychotic Drug Aripiprazole Protects Liver Cells from Oxidative Stress.International journal of molecular sciences · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Miguel González-MuñozImmunology Department La Paz-Cantoblanco-Carlos III University Hospital IdiPaz Madrid España.ORCID https://orcid.org/0000-0002-3957-4955
Jaime Monserrat VillatoroClinical Pharmacology Department Facultad de Medicina La Paz-Cantoblanco-Carlos III University Hospital IdiPaz Universidad Autónoma de Madrid Madrid España.
Eva Marín-SerranoGastroenterology and Hepatology Department La Paz-Cantoblanco-Carlos III University Hospital IdiPaz Madrid España.
Stefan StewartClinical Pharmacology Department Facultad de Medicina La Paz-Cantoblanco-Carlos III University Hospital IdiPaz Universidad Autónoma de Madrid Madrid España.
Belén Bardón RiveraPsiquiatry Department La Paz-Cantoblanco-Carlos III University Hospital, IdiPaz Madrid España.
Jesús MarínPsiquiatry Department La Paz-Cantoblanco-Carlos III University Hospital, IdiPaz Madrid España.
Lucía Martínez de SotoClinical Pharmacology Department Facultad de Medicina La Paz-Cantoblanco-Carlos III University Hospital IdiPaz Universidad Autónoma de Madrid Madrid España.
Enrique Seco MeseguerClinical Pharmacology Department Facultad de Medicina La Paz-Cantoblanco-Carlos III University Hospital IdiPaz Universidad Autónoma de Madrid Madrid España.
Elena RamírezClinical Pharmacology Department Facultad de Medicina La Paz-Cantoblanco-Carlos III University Hospital IdiPaz Universidad Autónoma de Madrid Madrid España.ORCID https://orcid.org/0000-0002-4052-8876
Universidad Autónoma de Madrid · ESHospital Universitario La Paz · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 56-year-old female patient was hospitalized because of a lack of response and poor tolerance to multiple antidepressants, which included an episode of DILI. During hospitalization, the patient suffered another episode of DILI. Causality was assessed both by RUCAM and Lymphocyte Transformation Test, allowing to identify a safer medication.

Indexed as

antidepressantscausality assessmentdrug‐induced liver injury (DILI)lymphocyte transformation test (LTT)pharmacovigilanceRoussel Uclaf Causality Assessment Method (RUCAM)

Identifiers

PMID33363890
PMCPMC7752543
OpenAlexW3088612484

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.