ArticleFrontiers in immunology2020
Change of Serum Metabolome and Cecal Microflora in Broiler Chickens Supplemented With Grape Seed Extracts.
Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Grapes and their by-products effects on growth performance, intestinal histomorphology, immune response and antioxidant status in broiler chickens - A meta-analysis.Poultry science · 2026Pooled it
- Tiny but Mighty: A Low Dose of Standardized Dry Grape Extract Potentiates Antioxidant Defenses in Broiler Chickens.Antioxidants (Basel, Switzerland) · 2026Article
- Effects of Fermented Grape Seed in Breeding-Pigeon Diets on Growth Performance, Immune Responses, and Oxidative Status of Offspring Squabs.Animals : an open access journal from MDPI · 2026Article
- Polyphenols regulate bone health through the gut-bone axis: molecular and applications in animal nutrition.Journal of animal science and biotechnology · 2026Review
- Effects of tea polyphenols on intestinal barrier, antioxidant capacity, and cecal microbiota in lion-head geese.Poultry science · 2026Article
- Procyanidin-B1-EnrichedAnimals : an open access journal from MDPI · 2025Article
- Efficacy of Feeding Grape By-Products on Performance, Nutrient Digestibility, Gut Morphology, Gut Microbial Community, Oxidative Stress and Immune Response in Fast-Growing Broilers.Animals : an open access journal from MDPI · 2025Review
- Effects of Grape By-Products on Oxidative Stress and Inflammation in Farm Animals: An Overview of Studies Performed in Pigs, Chickens, and Cattle.Animals : an open access journal from MDPI · 2025Review
- Effects of Grape Seed Proanthocyanidins on Growth Performance, Jejunal Antioxidant Capacity, Gut Microbial Diversity, and Metabolites in Kangle Chickens.Animals : an open access journal from MDPI · 2025Article
- Exploring the Association Between Human Blood Metabolites and Autism Spectrum Disorder Risk: A Bidirectional Mendelian Randomization Study.Health science reports · 2025Article
- Modulation of Immune Response and Cecal Microbiota by Dietary Fenugreek Seeds in Broilers.Veterinary sciences · 2024Article
- Impact of feed additives and host-related factors on bacterial metabolites, mucosal integrity and immune response in the ileum of broilers.Veterinary research communications · 2023Article
- Effects of Yupingfeng Polysaccharides as Feed Supplement on Immune Function and Intestinal Microbiome in Chickens.Microorganisms · 2023Article
- Oligomeric Proanthocyanidins: An Updated Review of Their Natural Sources, Synthesis, and Potentials.Antioxidants (Basel, Switzerland) · 2023Review
- Comparison of the Effects between Tannins Extracted from Different Natural Plants on Growth Performance, Antioxidant Capacity, Immunity, and Intestinal Flora of Broiler Chickens.Antioxidants (Basel, Switzerland) · 2023Article
- Dietary Epimedium extract supplementation improves intestinal functions and alters gut microbiota in broilers.Journal of animal science and biotechnology · 2023Article
- Feeding broilers with wheat germ, hops and grape seed extract mixture improves growth performance.Frontiers in physiology · 2023Article
- Anise and grape seed oils as a feed additive to improve the performance, immune response, and antioxidant activity and reduce caecal pathogenic microbes of quail.Archives animal breeding · 2023Article
- Improving productive performance, immunity, and health status of growing rabbits by using honey bee venom (Frontiers in veterinary science · 2023Article
- Grape By-Products as Feedstuff for Pig and Poultry Production.Animals : an open access journal from MDPI · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Grape seed is rich in vitamin E, flavonoids, and proanthocyanidins and has the potential to be used as an antibiotic substitute in broilers. We investigated the effects of grape seed proanthocyanidin extract (GSPE) on growth performance, immune responses, cecal microflora, and serum metabolism in early stage broilers. Data indicated that GSPE improved broiler growth performance by strengthening antioxidant capacity, enhancing immune responses, and increasing cecal short chain fatty acids. 16S rRNA sequencing indicated that GSPE changed the predominant cecal microflora and induced the metabolism of amino acids, lipids, and carbohydrates. An UPLC-Q-TOF/MS-based metabolomics analysis identified 23 serum metabolites (mainly related to lipid, amino acid, and alkaloid) were extremely changed by GSPE treatment. The correlations between the changes of cecal microflora and serum metabolites in birds fed with GSPE were analyzed. Hence, GSPE potentially provides active ingredients that may be used as antibiotic substitute and reduces environmental pollution by grape by-products.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.