ReviewFrontiers in immunology2020
Oral Dysbiosis and Autoimmunity: From Local Periodontal Responses to an Imbalanced Systemic Immunity. A Review.
Review in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed, 4 syntheses or guidelines pooled it, 113 citations in OpenAlex.
- Oral Microbiome in Systemic Autoimmune Diseases: A Systematic Review.Oral diseases · 2026Pooled it
- Advances in the study of oral microbiota in association with T2DM: a systematic review.Frontiers in cellular and infection microbiology · 2025Pooled it
- Advances in the study of oral microbiota and metabolism associated fatty liver disease: a systematic review.Frontiers in cellular and infection microbiology · 2024Pooled it
- Periodontal Disease in Patients with Psoriasis: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Association between salivary alkaline phosphatase levels and periodontal disease: a systematic review and meta-analysis.BDJ open · 2026Article
- Association between self-reported oral health issues and autoimmune diseases: evidence from UK biobank.BMC oral health · 2026Article
- Common Inflammatory Pathways Between Periodontal Disease and Multiple Sclerosis: A Systematic Review.Diseases (Basel, Switzerland) · 2026Review
- Holobiontic Intercellular Relationships Between the Oral Cavity and the Rest of the Human Organism: A Narrative Review.Medicina (Kaunas, Lithuania) · 2026Review
- Evaluating the Impact of Little Cigar Use on the Oral Bacterial Microbiota of Cigarette Smokers.Pathogens (Basel, Switzerland) · 2026Article
- The integrative role of the microbiome in systemic immuno-inflammatory aberrations.Folia microbiologica · 2026Review
- Tobacco-Induced Oral Dysbiosis and Microbial Shifts: A Narrative Review of Their Role in Systemic Inflammation and Disease.Microorganisms · 2026Review
- Gestational diabetes alters subgingival pathobiont composition.Acta odontologica Scandinavica · 2026Article
- Histological analysis of periodontal tissues in patients with autoimmune diseases: a comparative cross-sectional study of inflammatory cell infiltration and epithelial barrier function.BMC oral health · 2026Article
- Metronidazole-Loaded Cyclodextrin Nanogels for Antibacterial Therapy and Microbiota Regulation in Periodontitis.Advanced healthcare materials · 2026Article
- Dental infection is associated with early relapse in patients with ANCA-associated vasculitis.RMD open · 2026Article
- Periodontal disease-associated oral and gut microbiome changes in female rheumatoid arthritis patients.BMC oral health · 2026Article
- Coaxial electrospinning of poly(ɛ-caprolactone)/gelatin core-shell biodegradable implants for localized delivery of metronidazole and dexamethasone for periodontal applications.Frontiers in bioengineering and biotechnology · 2026Article
- Beyond receptor activation: biased toll-like receptor signaling in periodontal inflammation and regeneration.Frontiers in immunology · 2026Review
- Oral-Gut Microbiota Crosstalk and Epigenetic Targets in Metabolic and Neuropsychiatric Diseases.Nutrients · 2025Review
- Differential Patterns of Gut and Oral Microbiomes in Hispanic Individuals with Cognitive Impairment.Microorganisms · 2025Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The current paradigm of onset and progression of periodontitis includes oral dysbiosis directed by inflammophilic bacteria, leading to altered resolution of inflammation and lack of regulation of the inflammatory responses. In the construction of explanatory models of the etiopathogenesis of periodontal disease, autoimmune mechanisms were among the first to be explored and historically, for more than five decades, they have been described in an isolated manner as part of the tissue damage process observed in periodontitis, however direct participation of these mechanisms in the tissue damage is still controversial. Autoimmunity is affected by genetic and environmental factors, leading to an imbalance between the effector and regulatory responses, mostly associated with failed resolution mechanisms. However, dysbiosis/infection and chronic inflammation could trigger autoimmunity by several mechanisms including bystander activation, dysregulation of toll-like receptors, amplification of autoimmunity by cytokines, epitope spreading, autoantigens complementarity, autoantigens overproduction, microbial translocation, molecular mimicry, superantigens, and activation or inhibition of receptors related to autoimmunity by microorganisms. Even though autoreactivity in periodontitis is biologically plausible, the associated mechanisms could be related to non-pathologic responses which could even explain non-recognized physiological functions. In this review we shall discuss from a descriptive point of view, the autoimmune mechanisms related to periodontitis physio-pathogenesis and the participation of oral dysbiosis on local periodontal autoimmune responses as well as on different systemic inflammatory diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.