ArticleMolecular and cellular biology1988
Comparison of nonerythroid alpha-spectrin genes reveals strict homology among diverse species.
Article in Molecular and cellular biology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 78 citations in OpenAlex.
- Review
- Post-mortem detection of neuronal and astroglial biochemical markers in serum and urine for diagnostics of traumatic brain injury.International journal of legal medicine · 2023Article
- A Fresh Look at the Structure, Regulation, and Functions of Fodrin.Molecular and cellular biology · 2020Review
- The Role of Nonerythroid SpectrinJournal of oncology · 2019Review
- αII-spectrin and βII-spectrin do not affect TGFβ1-induced myofibroblast differentiation.Cell and tissue research · 2018Article
- Measurements of three-dimensional refractive index tomography and membrane deformability of live erythrocytes from Pelophylax nigromaculatus.Scientific reports · 2018Article
- The role of βII spectrin in cardiac health and disease.Life sciences · 2018Review
- Organization and dynamics of tryptophan residues in brain spectrin: novel insight into conformational flexibility.Journal of fluorescence · 2015Article
- Proteomic analysis of the differences in orbital protein expression in thyroid orbitopathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2013Article
- Developmental expression of spectrins in rat skeletal muscle.Molecular biology of the cell · 1998Article
- Urogenital syndrome (us): a developmental mutation on chromosome 2 of the mouse.Mammalian genome : official journal of the International Mammalian Genome Society · 1993Article
- Comparative map for mice and humans.Mammalian genome : official journal of the International Mammalian Genome Society · 1992Review
- Brain beta spectrin isoform 235 (Spnb-2) maps to mouse chromosome 11.Mammalian genome : official journal of the International Mammalian Genome Society · 1992Article
- The spectrin skeleton: from red cells to brain.The Journal of clinical investigation · 1991Review
- Mouse chromosome 2.Mammalian genome : official journal of the International Mammalian Genome Society · 1991Review
- Comparative map for mice and humans.Mammalian genome : official journal of the International Mammalian Genome Society · 1991Review
- A beta-spectrin isoform from Drosophila (beta H) is similar in size to vertebrate dystrophin.The Journal of cell biology · 1990Article
- Genes for two autosomal recessive forms of chronic granulomatous disease assigned to 1q25 (NCF2) and 7q11.23 (NCF1).American journal of human genetics · 1990Article
- Protection against streptococcal cell wall-induced arthritis by pretreatment with the 65-kD mycobacterial heat shock protein.The Journal of experimental medicine · 1989Article
- Primary structure of the brain alpha-spectrin.The Journal of cell biology · 1989Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
The spectrins are a family of widely distributed filamentous proteins. In association with actin, spectrins form a supporting and organizing scaffold for cell membranes. Using antibodies specific for human brain alpha-spectrin (alpha-fodrin), we have cloned a rat brain alpha-spectrin cDNA from an expression library. Several closely related human clones were also isolated by hybridization. Comparison of sequences of these and other overlapping nonerythroid and erythroid alpha-spectrin genes demonstrated that the nonerythroid genes are strictly conserved across species, while the mammalian erythroid genes have diverged rapidly. Peptide sequences deduced from these cDNAs revealed that the nonerythroid alpha-spectrin chain, like the erythroid spectrin, is composed of multiple 106-amino-acid repeating units, with the characteristic invariant tryptophan as well as other charged and hydrophobic residues in conserved locations. However, the carboxy-terminal sequence varies markedly from this internal repeat pattern and may represent a specialized functional site. The nonerythroid alpha-spectrin gene was mapped to human chromosome 9, in contrast to the erythroid alpha-spectrin gene, which has previously been assigned to a locus on chromosome 1.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.